Eif5a^tm1.1Tlm
Targeted Allele Detail

Summary

• Symbol: Eif5a^tm1.1Tlm
• Name: eukaryotic translation initiation factor 5A; targeted mutation 1.1, Teresa L Mastracci
• MGI ID: MGI:6831042
• Synonyms: Eif5a^loxP
• Gene: Eif5a Location: Chr11:69807540-69812784 bp, - strand Genetic Position: Chr11, 42.92 cM
• Alliance: Eif5a^tm1.1Tlm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:309372
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129/SvEv x C57BL/6)

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4, and an FRT/loxP flanked neomycin selection cassette was inserted downstream of exon 7. The selection cassette was removed via Flp-mediated recombination leaving exons 4 to 7 floxed. (J:309372)

Expression

In Mice Carrying this Mutation:

30 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Eif5a Mutation: 13 strains or lines available

Notes

ES cells = iTL HF4

References

• Original: J:309372 Padgett LR, et al., Deoxyhypusine synthase, an essential enzyme for hypusine biosynthesis, is required for proper exocrine pancreas development. FASEB J. 2021 May;35(5):e21473
• All: 2 reference(s)