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Gene Expression Data
Assay Details
Assay
Reference: J:267027 Nureki SI, et al., Expression of mutant Sftpc in murine alveolar epithelia drives spontaneous lung fibrosis. J Clin Invest. 2018 Aug 31;128(9):4008-4024
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6740378
Gene symbol: Sftpc
Gene name: surfactant associated protein C
Antibody: anti-proSP-C
Detection system: Secondary antibody coupled to Alexa Fluor 594
Results
Specimen 1D WT: postnatal week 8 (more )
Structure Level Pattern Image Note
TS28: alveolus epithelium Present Regionally restricted 1D WT Expression is in lamellar bodies in alveolar type II cells.
Specimen 1D I73T: postnatal week 8; Sftpctm1Mfbs/Sftpctm1Mfbs (more )
Structure Level Pattern Image Note
TS28: alveolus epithelium Present Regionally restricted 1D I73T Expression is at the plasma membrane in alveolar type II cells.
Specimen S3D WT/WT: postnatal week 32 (more )
Structure Level Pattern Image Note
TS28: alveolus epithelium Present Regionally restricted S3D WT/WT Expression is in alveolar type II cells.
Specimen S3D I73T/I73T: postnatal week 32; Sftpctm1Mfbs/Sftpctm1Mfbs (more )
Structure Level Pattern Image Note
TS28: alveolus epithelium Strong Regionally restricted S3D I73T/I73T The number of positive cells has increased in this mutant compared to wild-type.
Specimen Table I73T/I73T: postnatal week 16; Sftpctm1Mfbs/Sftpctm1Mfbs (more )
Structure Level Pattern Image Note
TS28: alveolus epithelium Strong Regionally restricted The number of positive cells has increased in this mutant compared to wild-type.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory