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Gene Expression Data
Assay Details
Assay
Reference: J:154915 Morrison KM, et al., Mammalian Merkel cells are descended from the epidermal lineage. Dev Biol. 2009 Dec 1;336(1):76-83
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:6716255
Gene symbol: Atoh1
Gene name: atonal bHLH transcription factor 1
Reporter: lacZ
Direct Detection
Results
Specimen E13.5 LacZ/+ not shown: embryonic day 13.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS22: back skin Absent No expression in whisker follicles or body skin of E13.5 embryos of either genotype.
TS22: vibrissa follicle Absent No expression in whisker follicles or body skin of E13.5 embryos of either genotype.
Specimen E13.5 LacZ/LacZ not shown: embryonic day 13.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS22: back skin Absent No expression in whisker follicles or body skin of E13.5 embryos of either genotype.
TS22: vibrissa follicle Absent No expression in whisker follicles or body skin of E13.5 embryos of either genotype.
Specimen 1A: embryonic day 14.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Present 1A Expression first seen in whisker follicles of both genotypes at E14.5.
Specimen 1B: embryonic day 14.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Strong Regionally restricted 1B Strong cellular expression in upper portions of whisker follicles.
Specimen 1C: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS23: vibrissa follicle Strong 1C Expression increased compared to E14.5.
Specimen 1D: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS23: vibrissa follicle Strong Regionally restricted 1D Strong cellular expression in upper portions of whisker follicles.
Specimen 1E: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS23: forelimb skin Present Regionally restricted 1E Expression in touch domes first seen at E15.5 in both genotypes.
Specimen 1F: embryonic day 15.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS23: skin Strong Regionally restricted 1F Strong expression in multiple cells within developing touch domes.
Specimen 1G: embryonic day 14.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Present 1G Expression first seen in whisker follicles of both genotypes at E14.5.
Specimen 1H: embryonic day 14.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS22: vibrissa follicle Present Punctate 1H Expression of single cells replaced by punctate expression of lesser intensity.
Specimen 1I: embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS23: vibrissa follicle Present Regionally restricted 1I Expression increased compared to E14.5.
Specimen 1J: embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS23: vibrissa follicle Present Punctate 1J Expression of single cells replaced by punctate expression of lesser intensity.
Specimen 1K: embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS23: forelimb skin Present Regionally restricted 1K Expression in touch domes first seen at E15.5 in both genotypes.
Specimen 1L: embryonic day 15.5; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS23: trunk skin Present Punctate 1L Expression in touch domes. Expression of single cells replaced by punctate expression of lesser intensity.
Specimen 3A: embryonic day 16.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS24: embryo Present Regionally restricted 3A Identical expression pattern in control and CKO embryos.
Specimen 3A': embryonic day 16.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS24: vibrissa follicle Strong 3A'
Specimen 3A'': embryonic day 16.5; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS24: trunk skin Strong Regionally restricted 3A'' Robust expression in touch domes.
Specimen 3B: embryonic day 16.5; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: embryo Present Regionally restricted 3B Identical expression pattern in control and CKO embryos.
Specimen 3B': embryonic day 16.5; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: vibrissa follicle Strong 3B'
Specimen 3B'': embryonic day 16.5; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS24: trunk skin Strong Regionally restricted 3B'' Robust expression in touch domes.
Specimen 3C (upper): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: vibrissa follicle Strong 3C (upper)
Specimen 3C (lower): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: vibrissa follicle Strong 3C (lower)
Specimen 3E (upper): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: skin Strong Regionally restricted 3E (upper) Robust expression in touch domes.
Specimen 3E (lower): postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: skin Strong Regionally restricted 3E (lower) Robust expression in touch domes.
Specimen S1A: postnatal day 0; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Present S1A
TS27: cochlear nucleus Present S1A
TS27: cuneate nucleus Present S1A
Specimen S1B: postnatal day 0; Atoh1tm2Hzo/Atoh1tm3Hzo, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Absent S1B
TS27: cochlear nucleus Absent S1B
TS27: cuneate nucleus Absent S1B
Specimen S1C: postnatal day 0; Atoh1tm2Hzo/Atoh1tm2Hzo (more )
Structure Level Pattern Image Note
TS27: cerebellum external granule cell layer Absent S1C
TS27: cochlear nucleus Absent S1C
TS27: cuneate nucleus Absent S1C
Specimen 4A: postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: back skin Present Regionally restricted 4A Expression in touch dome of body skin.
Specimen 4B (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: back skin Strong Single cells 4B (upper) Strong expression in individual cells in touch dome of body skin.
Specimen 4B (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: back skin Strong Single cells 4B (lower) Strong expression in individual cells in touch dome of body skin.
Specimen 4D: postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: back skin Present Regionally restricted 4D Expression in touch dome of body skin. Only minor difference compared to control.
Specimen 4E (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: back skin Present Punctate 4E (upper) Punctate expression in touch dome of body skin.
Specimen 4E (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: back skin Present Punctate 4E (lower) Punctate expression in touch dome of body skin.
Specimen 4G: postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: vibrissa follicle Present 4G
Specimen 4H (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: vibrissa follicle Strong Single cells 4H (upper) Strong expression in individual cells in vibrissa follicle.
Specimen 4H (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: vibrissa follicle Strong Single cells 4H (lower) Strong expression in individual cells in vibrissa follicle.
Specimen 4J: postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present 4J Only minor difference compared to control.
Specimen 4K (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Punctate 4K (upper)
Specimen 4K (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: vibrissa follicle Present Punctate 4K (lower)
Specimen 4M: postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted 4M Expression in rete ridges (epithelial invaginations).
Specimen 4N (upper): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: metapodial pad Strong Single cells 4N (upper) Strong expression in individual cells in rete ridges of feet.
Specimen 4N (lower): postnatal adult; Atoh1tm2Hzo/Atoh1+ (more )
Structure Level Pattern Image Note
TS28: metapodial pad Strong Single cells 4N (lower) Strong expression in individual cells in rete ridges of feet.
Specimen 4P: postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: metapodial pad Present Regionally restricted 4P Expression in rete ridges. Only minor difference compared to control.
Specimen 4Q (upper): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: metapodial pad Present Punctate 4Q (upper) Punctate expression in rete ridge.
Specimen 4Q (lower): postnatal adult; Atoh1tm2Hzo/Atoh1tm3Hzo, Tg(KRT14-cre)1Amc/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS28: metapodial pad Present Punctate 4Q (lower) Punctate expression in rete ridge.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory