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Gene Expression Data
Assay Details
Assay
Reference: J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6450184
Gene symbol: Cabp5
Gene name: calcium binding protein 5
Antibody: Anti-Cabp5
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3G: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Note: Double labeled: red - Cabp5; green - Irx6 (assay MGI:6450171).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 3I , 3G Cabp5 labels type 3a, 3b, 5, and rod bipolar cells. Cabp5 co-labeled with Irx6:b-gal positive cells in a subset of bipolar cells.
Specimen 5G: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Structure Level Pattern Image Note
TS28: retina inner plexiform layer Present Regionally restricted 5G Expression was detected in the region of the inner plexiform layer occupied by the axon terminal of type 3 and 5 and rod bipolar cells.
Specimen 5H: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Structure Level Pattern Image Note
TS28: retina inner plexiform layer Present Regionally restricted 5H Expression was reduced in the region of the inner plexiform layer occupied by the axon terminal of type 3 cells. Expression was unaffected in the regions of the axon termini of type 5 and rod bipolar cells.
Specimen 6C/D: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Note: Triple labeled: blue - Cabp5; green - Irx6 (assay MGI:6450171); red - Hcn4 (assay MGI:6450186).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 6C , 6D Type 3a bipolar cells were shown to be triple labeled by Cabp5, Hcn4, and Irx6:b-gal.
Specimen 6I/J: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Note: Triple labeled: blue - Cabp5; green - Irx6 (assay MGI:6450171); red - Hcn4 (assay MGI:6450186).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Weak Regionally restricted 6J , 6I In the mutant, Cabp5 expression was reduced in type 3a cells.
Specimen 6E/F: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Note: Triple labeled: blue - Cabp5; green - Irx6 (assay MGI:6450171); red - Prkar2b (assay MGI:6450187).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 6F , 6E Cabp5 was detected in Type 3a and 3b bipolar cells. Expression co-localized with Irx6:b-gal in type 3a cells and with Prkar2b in type 3b cells.
Specimen 6K/L: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Note: Triple labeled: blue - Cabp5; green - Irx6 (assay MGI:6450171); red - Prkar2b (assay MGI:6450187).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Weak Regionally restricted 6L , 6K In the mutant, Cabp5 expression was reduced in type 3a cells, but there was no change in type 3b cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory