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Gene Expression Data
Assay Details
Assay
Reference: J:189955 Star EN, et al., Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012 Dec;139(24):4644-55
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6450187
Gene symbol: Prkar2b
Gene name: protein kinase, cAMP dependent regulatory, type II beta
Antibody: Anti-PKA RII beta (pS114) (clone 47/PKA; 612550)
Detection system: Secondary antibody coupled to Alexa Fluor
Results
Specimen 3M: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Note: Double labeled: red - Prkar2b; green - Irx6 (assay MGI:6450171).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 3O , 3M Prkar2b labels type 3b bipolar cells. Prkar2b does not co-label with Irx6: b-gal positive bi-polar cells.
Specimen 6F: postnatal month 2-3; Irx6tm1Chow/Irx6+ (more )
Note: Triple labeled: red - Prkar2b; green - Irx6 (assay MGI:6450171); blue - Cabp5 (assay MGI:6450184).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 6F Expression was detected in type 3b bipolar cells.
Specimen 6L: postnatal month 2-3; Irx6tm1Chow/Irx6tm1Chow (more )
Note: Triple labeled: red - Prkar2b; green - Irx6 (assay MGI:6450171); blue - Cabp5 (assay MGI:6450184).
Structure Level Pattern Image Note
TS28: retina inner nuclear layer Present Regionally restricted 6L There was no change in expression in type 3b bipolar cells in the mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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05/14/2024
MGI 6.23 		The Jackson Laboratory