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Gene Expression Data
Assay Details
Assay
Reference: J:138715 Li WY, et al., Signaling through Tgf-beta type I receptor Alk5 is required for upper lip fusion. Mech Dev. 2008 Sep-Oct;125(9-10):874-82
Assay type: RNA in situ
MGI Accession ID: MGI:6441969
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe90
Probe preparation: Antisense labelled with digoxigenin RNA
Visualized with: Alkaline phosphatase
Results
Specimen 2A: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: 1st branchial arch mandibular component ectoderm Present Regionally restricted 2A Expression in surface ectoderm covering maxillary process.
TS16: latero-nasal process ectoderm Present Regionally restricted 2A Expression encroaching antero-superiorly onto lateral border of lateral nasal process.
Specimen 2B: embryonic day 10.0; Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl, Tg(Nes-cre)1Atp/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: 1st branchial arch maxillary component ectoderm Weak Regionally restricted 2B Reduced expression in facial region, limited to lower border of maxillary process.
Specimen 2C: embryonic day 10.0 (more )
Structure Level Pattern Image Note
TS16: 1st branchial arch maxillary component ectoderm Present Regionally restricted 2C Expression in surface ectoderm covering maxillary process.
TS16: latero-nasal process ectoderm Present Regionally restricted 2C Expression encroaching antero-superiorly onto lateral border of lateral nasal process.
Specimen 2D: embryonic day 10.0; Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl, Tg(Nes-cre)1Atp/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS16: 1st branchial arch maxillary component ectoderm Weak Regionally restricted 2D Reduced expression in facial region, limited to lower border of maxillary process.
Specimen 2E: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: vibrissa follicle Present 2E
Specimen 2F: embryonic day 12.0; Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl, Tg(Nes-cre)1Atp/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: vibrissa follicle Weak 2F Decreased expression in whisker follicle.
Specimen 2G: embryonic day 12.0 (more )
Structure Level Pattern Image Note
TS20: lip Ambiguous 2G
Specimen 2H: embryonic day 12.0; Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl, Tg(Nes-cre)1Atp/0 (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: lower lip Present Regionally restricted 2H Expression along entire edges of both upper and lower lips.
TS20: upper lip Present Regionally restricted 2H Expression along entire edges of both upper and lower lips.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory