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Gene Expression Data
Assay Details
Assay
Reference: J:150759 Lallemand Y, et al., Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 2009 Jul 15;331(2):189-98
Assay type: RNA in situ
MGI Accession ID: MGI:6404402
Gene symbol: Fgf8
Gene name: fibroblast growth factor 8
Results
Specimen 5G Forelimb Control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 5G FL Control
Specimen 5G Forelimb Shh-/-: embryonic day 11.5; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Trace Regionally restricted 5G FL Shh-/- Expression limited to single posteriorly localized spot
Specimen 5G Forelimb Shh-/-Msx1-/-Msx2+/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Trace Regionally restricted 5G FL Shh-/- Msx1-/- Msx2+/-
Specimen 5G Forelimb Shh-/-Msx1-/-Msx2-/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present Regionally restricted 5G FL Shh-/- Msx1-/- Msx2-/- Normal expression recovered, slightly stronger than in Shh-/- mutant.
Specimen 5G Hindlimb Control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5G HL Control
Specimen 5G Hindlimb Shh-/-: embryonic day 11.5; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Weak 5G HL Shh-/- Expression only slightly reduced.
Specimen 5G Hindlimb Shh-/-Msx1-/-Msx2+/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5G HL Shh-/- Msx1-/- Msx2+/-
Specimen 5G Hindlimb Shh-/-Msx1-/-Msx2-/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5G HL Shh-/- Msx1-/- Msx2-/- Normal expression recovered, slightly stronger than in Shh-/- mutant.
Specimen 5H Forelimb Control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 5H FL Control
Specimen 5H Forelimb Shh-/-: embryonic day 11.5; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Trace Regionally restricted 5H FL Shh-/- Expression limited to single posteriorly localized spot
Specimen 5H Forelimb Shh-/-Msx1-/-Msx2+/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Trace Regionally restricted 5H FL Shh-/- Msx1-/- Msx2+/-
Specimen 5H Forelimb Shh-/-Msx1-/-Msx2-/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: handplate apical ectodermal ridge Present 5H FL Shh-/- Msx1-/- Msx2-/- Normal expression recovered, slightly stronger than in Shh-/- mutant.
Specimen 5H Hindlimb Control: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5H HL Control
Specimen 5H Hindlimb Shh-/-: embryonic day 11.5; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Weak 5H HL Shh-/- Expression only slightly reduced.
Specimen 5H Hindlimb Shh-/-Msx1-/-Msx2+/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5H HL Shh-/- Msx1-/- Msx2+/-
Specimen 5H Hindlimb Shh-/-Msx1-/-Msx2-/-: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: footplate apical ectodermal ridge Present 5H HL Shh-/- Msx1-/- Msx2-/- Normal expression recovered, slightly stronger than in Shh-/- mutant.
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory