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Gene Expression Data
Assay Details
Assay
Reference: J:150759 Lallemand Y, et al., Msx genes are important apoptosis effectors downstream of the Shh/Gli3 pathway in the limb. Dev Biol. 2009 Jul 15;331(2):189-98
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6404247
Gene symbol: Casp3
Gene name: caspase 3
Results
Specimen 4A: embryonic day 10.75 (more )
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Ambiguous 4A
Specimen 4B: embryonic day 10.75; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Strong Regionally restricted 4B Intense expression in distal sub-apical ectodermal ridge (AER) region. Expression increased along whole proximo-distal axis in central region.
Specimen 4C: embryonic day 10.75; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Weak Regionally restricted 4C Expression almost absent in distal sub-apical ectodermal ridge (AER) region. Expression remained in proximal mesenchyme.
Specimen 4D: embryonic day 10.75; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS18: forelimb bud mesenchyme Weak Regionally restricted 4D Expression almost absent in distal sub-apical ectodermal ridge (AER) region. Expression remained in proximal mesenchyme.
Specimen 4E: embryonic day 11.25 (more )
Structure Level Pattern Image Note
TS19: hindlimb bud mesenchyme Ambiguous 4E
Specimen 4F: embryonic day 11.25; Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: hindlimb bud mesenchyme Strong Regionally restricted 4F Intense expression in distal sub-apical ectodermal ridge (AER) region.
Specimen 4G: embryonic day 11.25; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: hindlimb bud mesenchyme Trace Regionally restricted 4G No expression in in distal sub-apical ectodermal ridge (AER) region. Expression domain more polarized anteriorly.
Specimen 4H: embryonic day 11.25; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2tm1Bero, Shhtm1Amc/Shhtm1Amc (more )
Structure Level Pattern Image Note
TS19: hindlimb bud mesenchyme Trace Regionally restricted 4H No expression in in distal sub-apical ectodermal ridge (AER) region. Expression domain more polarized anteriorly.
Specimen 6E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Present Regionally restricted 6E Anterior expression domain corresponding to presumptive digit 1 territory, as well as a central domain of expression.
Specimen 6F: embryonic day 11.5; Msx1tm1Bero/Msx1tm1Bero, Msx2tm1Bero/Msx2+ (more )
Structure Level Pattern Image Note
TS19: hindlimb bud Present Regionally restricted 6F Anterior expression domain almost completely abolished in mutant; central domain of expression maintained.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory