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Gene Expression Data
Assay Details
Assay
Reference: J:269500 Hao MM, et al., Arundic Acid Prevents Developmental Upregulation of S100B Expression and Inhibits Enteric Glial Development. Front Cell Neurosci. 2017;11:42
Assay type: Immunohistochemistry
MGI Accession ID: MGI:6403766
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Antibody: anti-Sox10 (N-20, sc-17342)
Detection system: Secondary antibody coupled to Alexa Fluor 488
Assay notes: Data was quantified in Fig. 1E.
Results
Specimen 1A: embryonic day 14.5; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS22: duodenum Present Regionally restricted 1A merge , 1A Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells.
TS22: enteric nervous system Present Regionally restricted 1A merge , 1A Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells.
Specimen 1B: embryonic day 16.5; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS24: duodenum Present 1B merge , 1B Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells. The proportion of Sox10+/GFP+ cells was similar as in E14.5.
TS24: myenteric nerve plexus Present 1B merge , 1B Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells. The proportion of Sox10+/GFP+ cells was similar as in E14.5.
Specimen 1C: postnatal day 0; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS27: duodenum Present 1C merge , 1C Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells.
TS27: myenteric nerve plexus Present 1C merge , 1C Sox10 Expressed in the myenteric plexus of the duodenum in both enteric glia and enteric neural crest-derived cells.
Specimen not shown: embryonic day 14.5; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS22: enteric nervous system Present Regionally restricted Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells.
TS22: large intestine Present Regionally restricted Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells.
Specimen not shown: embryonic day 16.5; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS24: colon Present Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells. Steadily decreased proportion of Sox10+/GFP+ cells.
TS24: myenteric nerve plexus Present Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells. Steadily decreased proportion of Sox10+/GFP+ cells.
Specimen not shown: postnatal day 0; Gt(ROSA)26Sortm38(CAG-GCaMP3)Hze/Gt(ROSA)26Sor+, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant. GFP reporter protein was expressed by all enteric neural crest-derived cells.
Structure Level Pattern Image Note
TS27: colon Present Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells. Steadily decreased proportion of Sox10+/GFP+ cells.
TS27: myenteric nerve plexus Present Expressed in the myenteric plexus of the colon in both enteric glia and enteric neural crest-derived cells. Steadily decreased proportion of Sox10+/GFP+ cells.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
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