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Gene Expression Data
Assay Details
Assay
Reference: J:139188 Zhao H, et al., TGF-beta type I receptor Alk5 regulates tooth initiation and mandible patterning in a type II receptor-independent manner. Dev Biol. 2008 Aug 1;320(1):19-29
Assay type: RNA in situ
MGI Accession ID: MGI:6390864
Gene symbol: Shh
Gene name: sonic hedgehog
Probe: Shh probe160
Probe preparation: labelled with digoxigenin DNA
Results
Specimen 2A: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: maxillary process Present Regionally restricted 2A Highly localized expression at sites of prospective incisors and molars.
Specimen 2B: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: maxillary process Present Regionally restricted 2B Localized expression in maxilla process.
Specimen 2C: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: mandibular process Present Regionally restricted 2C Highly localized expression at sites of prospective incisors and molars.
Specimen 2D: embryonic day 11.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: mandibular process Absent 2D
Specimen 2E: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: maxillary process Strong 2E Authors report increased intensity of expression in maxilla process.
Specimen 2F: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: maxillary process Present 2F
Specimen 2G: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: maxillary process Present 2G
TS20: mandibular process Strong 2G Authors report increased intensity of expression in mandible process.
Specimen 2H: embryonic day 12.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS20: maxillary process Present 2H
TS20: mandibular process Absent 2H
Specimen 2I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: maxilla Weak 2I Expression began to decreased in maxilla.
Specimen 2J: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: maxilla Strong 2J
Specimen 2K: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: mandible Absent 2K
Specimen 2L: embryonic day 13.5; H2az2Tg(Wnt1-cre)11Rth/H2az2+, Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS21: mandible Present 2L Expression clearly detectable in mandible.
Specimen 4E: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: dental placode Present 4E Expression in tooth germs.
Specimen 4F: embryonic day 11.5; Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm, H2az2Tg(Wnt1-cre)11Rth/H2az2+ (more )
Note: Conditional mutant.
Structure Level Pattern Image Note
TS19: dental placode Present 4F Expression in unaffected in mutant.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/18/2025
MGI 6.24 		The Jackson Laboratory