About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:149474 Schwarz Q, et al., Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia. Development. 2009 Jun;136(11):1785-9
Assay type: RNA in situ
MGI Accession ID: MGI:5751983
Gene symbol: Sox10
Gene name: SRY (sex determining region Y)-box 10
Probe: Sox10 cDNA7
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1A: embryonic day 9.5; Nrp1tm1Ddg/Nrp1+, Nrp2tm1Ddg/Nrp2+ (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1A Neural crest cells migrated normally into the anterior sclerotome.

Specimen 1D: embryonic day 9.5; Nrp1tm1Ddg/Nrp1+, Nrp2tm1Ddg/Nrp2+ (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1D Neural crest cells accumulated in the migration staging area next to the neural tube at the level of the intersomitic furrow, and clustered into sympathetic anlagen at the dorsal aorta.

Specimen 1G: embryonic day 9.5; Nrp1tm1Ddg/Nrp1+, Nrp2tm1Ddg/Nrp2+ (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1G Neural crest cells migrated normally into the anterior sclerotome.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1G Neural crest cells clustered into sympathetic anlagen at the dorsal aorta.

Specimen 1J: embryonic day 9.5; Nrp1tm1Ddg/Nrp1+, Nrp2tm1Ddg/Nrp2+ (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1J Neural crest cells accumulated in the migration staging area next to the neural tube at the level of the posterior sclerotome.

Specimen 1B: embryonic day 9.5; Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Widespread 1B Neural crest cells migrated in an almost continuous band along the rostrocaudal axis.

Specimen 1E: embryonic day 9.5; Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1E Neural crest cells accumulated in the migration staging area next to the neural tube at the level of the intersomitic furrow, but maintained a ventromedial path. Neural crest cells also clustered into sympathetic anlagen at the dorsal aorta.

Specimen 1H: embryonic day 9.5; Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1H Neural crest cells maintained a ventromedial path.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1H Neural crest cells clustered into sympathetic anlagen at the dorsal aorta.

Specimen 1K: embryonic day 9.5; Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1K Neural crest cells maintained a ventromedial path.
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1K Neural crest cells clustered into sympathetic anlagen at the dorsal aorta.

Specimen 1C: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1C Excess neural crest cells travelled through the intersomitic furrow on dorsolateral and ventromedial paths, few cells migrated into the anterior sclerotome.
TS15: sclerotome Present Regionally restricted 1C Few neural crest cells migrated into the anterior sclerotome.

Specimen 1F: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 1F Excess neural crest cells travelled through the intersomitic furrow on dorsolateral and ventromedial paths.

Specimen 1I: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1I Few neural crest cells migrated into the anterior sclerotome.

Specimen 1L: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 1L Neural crest cells accumulated in the migration staging area next to the neural tube at the level of the posterior sclerotome.

Specimen 3C: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 3C Neural crest cells preferentially migrated through the intersomitic furrow at caudal levels, but through both anterior and posterior sclerotome at rostral levels.

Specimen 3D: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 3D At forelimb level, both ectopic migratory patterns overlapped, with excess neural crest cells in the intersomitic furrow and invasion of both anterior and posterior sclerotome halves.

Specimen 3E: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 3E Neural crest cells invasion in anterior sclerotome.

Specimen 3F: embryonic day 9.5; Nrp1tm1Ddg/Nrp1tm1Ddg, Nrp2tm1Ddg/Nrp2tm1Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 3F Neural crest cells invasion in posterior sclerotome.

Specimen 3G: embryonic day 9.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag, Sema3ftm1.2Ddg/Sema3ftm1.2Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 3G Neural crest cells preferentially migrated through the intersomitic furrow at caudal levels, but through both anterior and posterior sclerotome at rostral levels.

Specimen 3H: embryonic day 9.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag, Sema3ftm1.2Ddg/Sema3ftm1.2Ddg (more )
Structure Level Pattern Image Note
TS15: trunk mesenchyme derived from neural crest Present Regionally restricted 3H At forelimb level, both ectopic migratory patterns overlapped, with excess neural crest cells in the intersomitic furrow and invasion of both anterior and posterior sclerotome halves.

Specimen 3I: embryonic day 9.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag, Sema3ftm1.2Ddg/Sema3ftm1.2Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 3I Neural crest cells invasion in anterior sclerotome.

Specimen 3J: embryonic day 9.5; Sema3atm1.1Tyag/Sema3atm1.1Tyag, Sema3ftm1.2Ddg/Sema3ftm1.2Ddg (more )
Structure Level Pattern Image Note
TS15: sclerotome Present Regionally restricted 3J Neural crest cells invasion in posterior sclerotome.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/25/2025
MGI 6.24
The Jackson Laboratory