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Gene Expression Data
Assay Details
Assay
Reference: J:33808 Moore MW, et al., Renal and neuronal abnormalities in mice lacking GDNF. Nature. 1996 Jul 4;382(6586):76-9
Assay type: Immunohistochemistry
MGI Accession ID: MGI:4451201
Gene symbol: Th
Gene name: tyrosine hydroxylase
Results
Specimen 1d: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: substantia nigra Present 1d
Specimen 1e: postnatal day 0; Gdnftm1Rosl/Gdnftm1Rosl (more )
Structure Level Pattern Image Note
TS27: substantia nigra Present 1e Authors report similar numbers of dopaminergic neurons compared with wild-type mice.
Specimen 1f: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: corpus striatum Present 1f
Specimen 1g: postnatal day 0; Gdnftm1Rosl/Gdnftm1Rosl (more )
Structure Level Pattern Image Note
TS27: corpus striatum Present 1g Authors report similar density of dopaminergic projections to the striatum compared with wild type mice.
Specimen 1j: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: locus coeruleus Present 1j
Specimen 1k: postnatal day 0; Gdnftm1Rosl/Gdnftm1Rosl (more )
Structure Level Pattern Image Note
TS27: locus coeruleus Present 1k
Specimen 1n: postnatal day 0 (more )
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present 1n
Specimen 1o: postnatal day 0; Gdnftm1Rosl/Gdnftm1Rosl (more )
Structure Level Pattern Image Note
TS27: superior cervical ganglion Present 1o
Specimen Table 1 P42 Wild-type: postnatal day 42 (more )
Structure Level Pattern Image Note
TS28: locus coeruleus Present
TS28: substantia nigra pars compacta Present
Specimen Table 1 P42 Wild-type: postnatal day 42; Gdnftm1Rosl/Gdnf+ (more )
Structure Level Pattern Image Note
TS28: locus coeruleus Present No statistically significant deficit in the number of dopaminergic neurons compared with wild type mice.
TS28: substantia nigra pars compacta Present No statistically significant deficit in the number of dopaminergic neurons compared with wild type mice.
Specimen not shown: postnatal day 42; Gdnftm1Rosl/Gdnf+ (more )
Structure Level Pattern Image Note
TS28: corpus striatum Present No decrease in the density of dopaminergic fibers compared with wild-type mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory