Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
cn1
cn2
cn3
cn4
cn5
cn6
cn7
cn8
cn9
cn10
cn11
cn12
cn13
cn14
cn15
cn16
cn17
cn18
cn19
cn20
cn21
cn22
cn23
cn24
cn25
cn26
cn27
cn28
cn29
cn30
cn31
cn32
show or hide all annotated terms Sex:
                                                               
cellular
√ √ √ √ N √ √
cellular phenotype
N
abnormal lysosome morphology
√
abnormal mesangial cell morphology
√
abnormal cell physiology
√
abnormal dendritic cell differentiation
√
abnormal leukocyte migration
√
abnormal dendritic cell migration
√ √
abnormal dendritic cell chemotaxis
√ √
digestive/alimentary system
√ √
decreased colon length
√ √
increased susceptibility to induced colitis
√ √
increased susceptibility to colitis induced morbidity/mortality
√
growth/size/body
√ √ √ √ √ √
increased susceptibility to weight loss
√
decreased body size
√
decreased body weight
√
enlarged spleen
√ √ √
hepatosplenomegaly
√
hematopoietic system
√ √ √ N √ N √ √ √ √ √ √ √ √ √ √ √ N N √ √
hematopoietic system phenotype
N N N N N
enlarged spleen
√ √ √
hepatosplenomegaly
√
myeloid hyperplasia
√
anemia
√
abnormal leukocyte morphology
√
abnormal dendritic cell differentiation
√
abnormal NK cell differentiation
√
abnormal T follicular helper cell differentiation
√
abnormal T-helper 1 cell differentiation
√
abnormal dendritic cell number
√
decreased dendritic cell number
√ √
increased dendritic cell number
√ √ √
increased plasmacytoid dendritic cell number
√
decreased NK cell number
√ √
abnormal T cell subpopulation ratio
√
decreased T helper 1 cell number
√ √
decreased T-helper 17 cell number
√
decreased CD8-positive, alpha-beta T cell number
√ √
decreased memory T cell number
√ √
increased leukocyte cell number
√
increased granulocyte number
√
increased neutrophil cell number
√ √
increased B cell number
√
increased germinal center B cell number
√
increased plasma cell number
√
increased T cell number
√ √
increased T follicular helper cell number
√
increased T-helper 17 cell number
√
increased memory T cell number
√
increased activated T cell number
√
increased monocyte cell number
√ √
increased Ly6C high monocyte number
√
abnormal regulatory T cell morphology
√
abnormal peritoneal macrophage morphology
√
increased spleen germinal center number
√
increased splenocyte number
√
abnormal leukocyte physiology
√
abnormal leukocyte migration
√
abnormal dendritic cell migration
√ √
abnormal dendritic cell chemotaxis
√ √
abnormal germinal center B cell physiology
√
decreased IgG1 level
√
decreased IgG2b level
√
decreased IgG2c level
√
increased immunoglobulin level
√ √
increased IgG level
√ √
abnormal NK cell physiology
√ √
abnormal CD4-positive, alpha-beta T cell physiology
√
abnormal T cell activation
√
abnormal hematopoietic stem cell physiology
√
homeostasis/metabolism
√ N √ √ √ √
homeostasis/metabolism phenotype
N
abnormal circulating cytokine level
√
abnormal circulating chemokine level
√
increased circulating interferon-gamma level
√
increased circulating interleukin-1 beta level
√ √
decreased circulating interleukin-12b level
√
increased circulating interleukin-12 level
√
increased circulating interleukin-17 level
√ √
increased circulating interleukin-18 level
√
decreased circulating interleukin-6 level
√
increased circulating interleukin-6 level
√ √
increased circulating tumor necrosis factor level
√ √
increased urine protein level
√
immune system
√ √ √ N √ N √ N √ √ N √ √ N √ √ √ √ √ √ √ √ √ N √ √ N N √ N √
immune system phenotype
N N N N N N N N N N N N N N
enlarged spleen
√ √ √
hepatosplenomegaly
√
myeloid hyperplasia
√
abnormal leukocyte morphology
√
abnormal dendritic cell differentiation
√
abnormal NK cell differentiation
√
abnormal T follicular helper cell differentiation
√
abnormal T-helper 1 cell differentiation
√
abnormal dendritic cell number
√
decreased dendritic cell number
√ √
increased dendritic cell number
√ √ √
increased plasmacytoid dendritic cell number
√
decreased NK cell number
√ √
abnormal T cell subpopulation ratio
√
decreased T helper 1 cell number
√ √
decreased T-helper 17 cell number
√
decreased CD8-positive, alpha-beta T cell number
√ √
decreased memory T cell number
√ √
increased leukocyte cell number
√
increased granulocyte number
√
increased neutrophil cell number
√ √
increased B cell number
√
increased germinal center B cell number
√
increased plasma cell number
√
increased T cell number
√ √
increased T follicular helper cell number
√
increased T-helper 17 cell number
√
increased memory T cell number
√
increased activated T cell number
√
increased monocyte cell number
√ √
increased Ly6C high monocyte number
√
abnormal regulatory T cell morphology
√
abnormal peritoneal macrophage morphology
√
increased spleen germinal center number
√
increased splenocyte number
√
decreased follicular dendritic cell number
√
enlarged lymph nodes
√ √ √ √
lymph node hyperplasia
√
abnormal immune system physiology
√ √
abnormal leukocyte physiology
√
abnormal leukocyte migration
√
abnormal dendritic cell migration
√ √
abnormal dendritic cell chemotaxis
√ √
abnormal germinal center B cell physiology
√
decreased IgG1 level
√
decreased IgG2b level
√
decreased IgG2c level
√
increased immunoglobulin level
√ √
increased IgG level
√ √
abnormal NK cell physiology
√ √
abnormal CD4-positive, alpha-beta T cell physiology
√
abnormal T cell activation
√
abnormal circulating cytokine level
√
abnormal circulating chemokine level
√
increased circulating interferon-gamma level
√
increased circulating interleukin-1 beta level
√ √
decreased circulating interleukin-12b level
√
increased circulating interleukin-12 level
√
increased circulating interleukin-17 level
√ √
increased circulating interleukin-18 level
√
decreased circulating interleukin-6 level
√
increased circulating interleukin-6 level
√ √
increased circulating tumor necrosis factor level
√ √
abnormal dendritic cell physiology
√ √ √ √
abnormal dendritic cell antigen presentation
√
abnormal cytokine secretion
√ √
increased interleukin-12 secretion
√
decreased interleukin-2 secretion
√
increased interleukin-23 secretion
√
increased interleukin-6 secretion
√ √ √
increased tumor necrosis factor secretion
√
decreased susceptibility to experimental autoimmune encephalomyelitis
√
increased susceptibility to autoimmune disorder
√
increased autoantibody level
√ √
increased anti-nuclear antigen antibody level
√
increased anti-double stranded DNA antibody level
√
decreased acute inflammation
√
chronic inflammation
√
granulomatous inflammation
√
increased inflammatory response
√ √
increased susceptibility to induced colitis
√ √
increased susceptibility to colitis induced morbidity/mortality
√
cytokine storm
√
liver inflammation
√
kidney inflammation
√
glomerulonephritis
√
lung inflammation
√
skin inflammation
√
decreased susceptibility to bacterial infection
√
increased susceptibility to bacterial infection
√
increased susceptibility to bacterial infection induced morbidity/mortality
√
decreased susceptibility to prion infection
√ √
increased susceptibility to Retroviridae infection
√
integument
√
skin inflammation
√
skin lesions
√
liver/biliary system
√ √
hepatosplenomegaly
√
liver inflammation
√
mortality/aging
√ N √ √ √
mortality/aging
N
increased susceptibility to colitis induced morbidity/mortality
√
increased susceptibility to bacterial infection induced morbidity/mortality
√
premature death
√ √
neoplasm
N
neoplasm
N
renal/urinary system
√ N √ √
renal/urinary system phenotype
N
increased urine protein level
√
kidney inflammation
√
glomerulonephritis
√
abnormal kidney morphology
√ √
abnormal mesangial cell morphology
√
renal glomerular immunoglobulin deposits
√
respiratory system
√
lung inflammation
√
skeleton
N
skeleton phenotype
N