Phenotypes Associated with This Genotype

Genotype
MGI:8246912

• Allelic Composition: Acsm3^em1Wayb/Acsm3^em1Wayb
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:365449 )

♂ • after 12 weeks on a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

increased liver weight ( J:365449 )

♂ • increased liver weight and liver/body weight ratio after 12 weeks on a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

behavior/neurological

decreased food intake ( J:365449 )

♂ • decreased average daily feed intake on a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

liver/biliary system

abnormal hepatocyte mitochondrial morphology ( J:365449 )

♂ • on a high fructose and high fat diet more abnormal mitochondria are seen along with increased mitochondrial perimeter and area

increased liver weight ( J:365449 )

♂ • increased liver weight and liver/body weight ratio after 12 weeks on a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

increased liver cholesterol level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased liver free fatty acids level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased liver triglyceride level ( J:365449 )

♂ • on a normal diet or on a high fructose and high fat diet

hepatic steatosis ( J:365449 )

♂ • lipid accumulation when on a high fructose and high fat diet

liver degeneration ( J:365449 )

♂ • significant increases in hepatocellular ballooning degeneration on a high fructose and high fat diet

abnormal hepatocyte physiology ( J:365449 )

♂ • decreased oxygen consumption rate in primary hepatoctes

♂ • higher levels of total and mitochondrial reactive oxygen species in primary hepatocytes

homeostasis/metabolism

decreased cellular ATP level ( J:365449 )

• in hepatocytes

increased circulating cholesterol level ( J:365449 )

♂ • on a high fructose and high fat diet but not on a normal diet

increased circulating HDL cholesterol level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased circulating LDL cholesterol level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased circulating free fatty acids level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased circulating triglyceride level ( J:365449 )

♂ • on a normal diet or on a high fructose and high fat diet

increased circulating alanine transaminase level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased circulating aspartate transaminase level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

decreased enzyme/coenzyme level ( J:365449 )

♂ • decreased liver acetyl coenzyme A when on a high fructose and high fat diet

decreased oxygen consumption ( J:365449 )

♂ • in primary hepatocytes

decreased respiratory quotient ( J:365449 )

♂

impaired glucose tolerance ( J:365449 )

♂ • larger glucose excursion in a glucose tolerance test

♂ • impaired on both a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

insulin resistance ( J:365449 )

♂ • decreased insulin sensitivity in an insulin tolerance test when on a normal diet or when fed a high fructose and high fat diet from 4 - 12 weeks of age

increased liver cholesterol level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased liver free fatty acids level ( J:365449 )

♂ • on a high fructose and high fat diet but not when on a normal diet

increased liver triglyceride level ( J:365449 )

♂ • on a normal diet or on a high fructose and high fat diet

cellular

decreased cellular ATP level ( J:365449 )

• in hepatocytes

abnormal hepatocyte mitochondrial morphology ( J:365449 )

♂ • on a high fructose and high fat diet more abnormal mitochondria are seen along with increased mitochondrial perimeter and area

abnormal mitochondrial physiology ( J:365449 )

♂ • decreased mitochondrial membrane potential in primary hepatocytes

oxidative stress ( J:365449 )

♂ • higher levels of total and mitochondrial reactive oxygen species in primary hepatocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome		DOID:0060611	OMIM:PS605552	J:365449