Acsm3^em1Wayb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acsm3^em1Wayb
• Name: acyl-CoA synthetase medium-chain family member 3; endonuclease-mediated mutation 1, Yibo Wang
• MGI ID: MGI:8246909
• Gene: Acsm3 Location: Chr7:119360106-119384119 bp, + strand Genetic Position: Chr7, 64.17 cM, cytoband F3
• Alliance: Acsm3^em1Wayb page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Not Specified
• Mutation details: CRISPR/cas9 mediated recombination targeting the first coding exon created a severely hypomorphic allele. Western blot analysis of liver extracts from homozygous mice showed severe depletion of expression. (J:365449)
• Inheritance: Not Specified

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acsm3 Mutation: 37 strains or lines available

References

• Original: J:365449 Xiao X, et al., Liver ACSM3 deficiency mediates metabolic syndrome via a lauric acid-HNF4alpha-p38 MAPK axis. EMBO J. 2024 Feb;43(4):507-532
• All: 1 reference(s)