Phenotypes Associated with This Genotype

Genotype
MGI:7736740

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)89.1Dam/0; Trp53^tm1Brn/Trp53⁺
• Genetic Background: involves: 129 * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:289183 )

• mice develop pancreatic cancer

increased pancreatic ductal adenocarcinoma incidence ( J:289183 )

• all pancreata of 7-month old mice are replaced by aggressive pancreatic ductal adenocarcinoma with lung and liver metastasis

• circulating pancreatic neoplastic cells are increased in the blood of mice harboring pancreatic adenocarcinoma

increased pancreatic intraepithelial neoplasia incidence ( J:289183 )

• 100% of 3-month old mice exhibit abundant acinar-ductal metaplasia and low- and high-grade pancreatic intraepithelial neoplasia (PanIN) lesions

mortality/aging

premature death ( J:289183 )

• average survival is 5.2 +/- 1.2 months

endocrine/exocrine glands

increased pancreas tumor incidence ( J:289183 )

• mice develop pancreatic cancer

increased pancreatic ductal adenocarcinoma incidence ( J:289183 )

• all pancreata of 7-month old mice are replaced by aggressive pancreatic ductal adenocarcinoma with lung and liver metastasis

• circulating pancreatic neoplastic cells are increased in the blood of mice harboring pancreatic adenocarcinoma

increased pancreatic intraepithelial neoplasia incidence ( J:289183 )

• 100% of 3-month old mice exhibit abundant acinar-ductal metaplasia and low- and high-grade pancreatic intraepithelial neoplasia (PanIN) lesions

pancreatic acinar-to-ductal metaplasia ( J:289183 )

• 100% of 3-month old mice exhibit abundant acinar-ductal metaplasia and low- and high-grade pancreatic intraepithelial neoplasia (PanIN) lesions

• circulating pancreatic neoplastic cells are increased in the blood of mice harboring PanI

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:289183