Phenotypes Associated with This Genotype

Genotype
MGI:6515651

cn251

• Allelic Composition: Usp20^em1Gpt/Usp20^em1Gpt; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: C57BL/6JGpt * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:299971 )

N • mice fed a high-fat and high-sucrose diet exhibit normal respiratory exchange ratio

decreased circulating glucose level ( J:299971 )

• in fasted and refed mice

decreased fasting circulating glucose level ( J:299971 )

• in fasted and refed mice

decreased circulating insulin level ( J:299971 )

• in refed mice

• however, fasted mice exhibit normal levels

decreased circulating cholesterol level ( J:299971 )

• in fasted and refed mice

• treatment with GSK2643943A does not alter cholesterol levels

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

decreased circulating HDL cholesterol level ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

decreased circulating LDL cholesterol level ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

decreased circulating free fatty acids level ( J:299971 )

• in fasted and refed mice

decreased circulating triglyceride level ( J:299971 )

• in fasted and refed mice

• treatment with GSK2643943A does not alter triglyceride levels

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

decreased circulating VLDL triglyceride level ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

increased body surface temperature ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

increased energy expenditure ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

• treatment with GSK2643943A does not ameliorate energy expenditure

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

abnormal enzyme/coenzyme level ( J:299971 )

• increased liver levels of HMG-CoA and succinate

• decreased liver levels of succinyl-CoA

abnormal circulating enzyme level ( J:299971 )

• doubled serum succinate levels

increased oxygen consumption ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

improved glucose tolerance ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

• treatment with GSK2643943A does not alter glucose clearance

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

increased insulin sensitivity ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

decreased liver cholesterol level ( J:299971 )

• in fasted and refed mice

decreased liver triglyceride level ( J:299971 )

• in fasted and refed mice

• decreased VLDL, LDL, and HDL

liver/biliary system

abnormal liver morphology ( J:299971 )

• reduced fat accumulation when mice are fed a high-fat and high-sucrose diet

decreased liver cholesterol level ( J:299971 )

• in fasted and refed mice

decreased liver triglyceride level ( J:299971 )

• in fasted and refed mice

• decreased VLDL, LDL, and HDL

decreased liver weight ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

growth/size/body

decreased body fat mass ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

decreased body weight ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

• however, lean body mass to body weight is normal

behavior/neurological

behavior/neurological phenotype ( J:299971 )

N • mice fed a high-fat and high-sucrose diet exhibit normal physical activity

adipose tissue

decreased body fat mass ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet

• however, adenoviral expression of HMGCR with the point mutation K248R exhibit rescued phenotype

decreased fat cell size ( J:299971 )

• reduced area

decreased white adipose tissue mass ( J:299971 )

• when mice are fed a high-fat and high-sucrose diet