Analysis Tools
hematopoietic system
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• splenomegaly in all terminally ill mice
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• plasma cell formation is severely impeded 10 days after primary and secondary immunization
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• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
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• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
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• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization
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immune system
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• splenomegaly in all terminally ill mice
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• plasma cell formation is severely impeded 10 days after primary and secondary immunization
|
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• mice show increased numbers of germinal center B cells at day 10 after primary immunizations
|
|
• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle
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• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization
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• occasional lymphadenopathy
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liver/biliary system
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• hepatomegaly in one mouse
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mortality/aging
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• shortened survival
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• shortened survival
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neoplasm
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• spleens and lymph nodes show presence of large cells with a diffuse growth pattern, resembling diffuse large B cell lymphoma (DLBCL)
• lymphoproliferations are of clonal origin
• 5 of 6 DLBCLs are consistent with activated B cell-DLBCL
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growth/size/body
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• hepatomegaly in one mouse
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• splenomegaly in all terminally ill mice
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