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Phenotypes Associated with This Genotype
Genotype
MGI:5688722
Allelic
Composition		 \Meikintm1Yow/\Meikintm1Yow
\Mlh1tm1Lisk/\Mlh1tm1Lisk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meikintm1Yow mutation (0 available); any Meikin mutation (19 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromosomal synapsis ( J:216866 )
• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin
• mono-orientation defect in spermatocytes

cellular
abnormal chromosomal synapsis ( J:216866 )
• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin
• mono-orientation defect in spermatocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory