Phenotypes Associated with This Genotype

Genotype
MGI:5563692

• Allelic Composition: Tg(SV40-KLK7)1010Teg/0
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

excessive scratching ( J:75714 )

• from 5-6 weeks of age, mice show signs of itch with scratching, the frequency of which increases with time

• 73% of mice show signs of itch at 10-11 weeks of age, with varied frequency of scratching

growth/size/body

decreased body weight ( J:75714 )

• 7-10% reduction in weight at 13-14 weeks of age

immune system

dermatitis ( J:75714 )

• at 3 weeks of age, skin shows a mild cellular inflammatory reaction with mixed leukocytes in the upper dermis

• increase in the number of mast cells in the dermis in some mice at 5 weeks of age

• leukocyte invasion of the epidermis is occasionally seen that then manifests as small groups of granulocytes within the thickened cornified layer, which is parakeratotic at these sites

integument

dermatitis ( J:75714 )

• at 3 weeks of age, skin shows a mild cellular inflammatory reaction with mixed leukocytes in the upper dermis

• increase in the number of mast cells in the dermis in some mice at 5 weeks of age

• leukocyte invasion of the epidermis is occasionally seen that then manifests as small groups of granulocytes within the thickened cornified layer, which is parakeratotic at these sites

abnormal coat appearance ( J:75714 )

• older mice exhibit a luster-less appearance of the coat

focal hair loss in head/neck region ( J:75714 )

• macroscopic skin changes become apparent at 4-5 weeks of age, with loss of hair from a narrow zone around the eyes

sparse hair ( J:75714 )

• older mice show thinning of body hair in general

hyperkeratosis ( J:75714 )

• at 3 weeks of age

acanthosis ( J:75714 )

• by 5 weeks of age, marked acanthosis-like hyperplasia and hyperkeratosis of the epidermis is seen

epidermal hyperplasia ( J:75714 )

• at 3 weeks of age, skin shows mild to moderate epidermal hyperplasia

thick epidermis ( J:75714 )

• increase in epidermal thickness at 7-8 weeks and 13-14 weeks of age

• increase in epithelial thickness of adnexal structures (hair follicle walls, and sebaceous glands and ducts)

scaly skin ( J:75714 )

• the skin surface on the back is covered in fine scales

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
atopic dermatitis		DOID:3310	OMIM:603165 OMIM:PS603165	J:75714