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Transgene Detail
Symbol: Tg(SV40-KLK7)1010Teg
Name: transgene insertion 1010, Torbjorn Egelrud
MGI ID: MGI:5563691
Synonyms: Tg1010SV40e-hscce
Transgene: Tg(SV40-KLK7)1010Teg  Location: unknown  
Alliance: Tg(SV40-KLK7)1010Teg page
Strain of Origin:  (C57BL/6J x CBA)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(SV40-KLK7)1010Teg expresses 1 gene
Mutation detailsThe human KLK7 cDNA is under the control of the SV40 early enhancer and promoter elements. Three lines were established; 103, 107, and 1010, however only this line shows a skin phenotype. Enzyme-linked immunosorbent assay confirmed protein expression in skin, intestines, and lung and immunoblotting indicates that proteolytically active enzyme is produced. (J:75714)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:75714 Hansson L, et al., Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: a model for chronic itchy dermatitis. J Invest Dermatol. 2002 Mar;118(3):444-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory