Analysis Tools
mortality/aging
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• while mice are present in Mendelian ratios at E12, fewer than expected mice survive after weaning
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reproductive system
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• enlarged epididymal canal in male mice
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• in male mice
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homeostasis/metabolism
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N |
• fasted male mice exhibit normal serum cholesterol levels
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in random-fed male mice starting at 9 weeks and worsening with age
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• in 4 month old fasted male mice
• however, pioglitazone treatment improves phenotype
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• at 2 months in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in 4 month old male mice
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• in 4 month old male mice
• however, pioglitazone treatment improves insulin sensitivity
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• at 2 months in the serum of male mice
• however, pioglitazone treatment improves phenotype
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• male mice exhibit increased triacylglycerol-rich lipoprotein clearance compared with wild-type mice
• hepatic lipid uptake in male mice is increased compared to in wild-type mice
• however, pioglitazone treatment improves lipid homeostasis
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• slight in male mice
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• fasted male mice at 2 months
• however, random fed mice exhibit normal levels
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• fasted and random-fed male mice at 2 months
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• in male mice
• however, pioglitazone treatment improves phenotype
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• mouse embryonic fibroblasts exhibit a 4-fold increase in basal glycerol release indicating increased basal lipolysis compared with wild-type cells
• however, isoprenaline-stimulated lipolysis is normal
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adipose tissue
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• in male mice
• however, pioglitazone treatment improves phenotype
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• following induction of adipocyte differentiation, mouse embryonic fibroblasts exhibit reduced triacylglycerol levels compared with wild-type cells
• however, thiazolidinediones partially restore adipocyte function in vitro
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• absent peri-gonadal fat pad in male mice
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
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• near total in 2 month old male mice
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liver/biliary system
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• in male mice
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• 2-fold in male mice
• however, pioglitazone treatment improves phenotype
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• in male mice
• however, pioglitazone treatment improves phenotype
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• however, pioglitazone treatment improves phenotype
• in male mice
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growth/size/body
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• in mice treated with pioglitazone
• however, untreated mice exhibit normal body weight
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• in male mice
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• 2-fold in male mice
• however, pioglitazone treatment improves phenotype
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behavior/neurological
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N |
• male mice exhibit normal activity levels
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• at 2 months in male mice
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digestive/alimentary system
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• enlarged in male mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital generalized lipodystrophy type 2 | DOID:0111136 |
OMIM:269700 |
J:200947 | |
