About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5504638
cn3
Allelic
Composition		 P4hbtm1.1Geno/P4hbtm1.2Geno
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lyz2tm1(cre)Ifo mutation (16 available); any Lyz2 mutation (40 available)
P4hbtm1.1Geno mutation (0 available); any P4hb mutation (33 available)
P4hbtm1.2Geno mutation (0 available); any P4hb mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells

hematopoietic system
decreased neutrophil cell number ( J:197556 )
• to the inflamed endothelium
impaired neutrophil recruitment ( J:197556 )
• during TNF-alpha-induced inflammation, mice exhibit increased rolling influx, reduced percentage of crawling cells among adherent neutrophils and reduced number of adherent neutrophils to the inflamed endothelium
• neutrophils exhibit reduced neutrophil adhesion to ICAM-1-coated surface compared with wild-type cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory