Phenotypes Associated with This Genotype

Genotype
MGI:5495326

• Allelic Composition: Cdc42^tm1.1Rac/Cdc42^tm1.1Rac; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:197886 )

• mice die within 72 hours of birth

nervous system

intraventricular hemorrhage ( J:197886 )

• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain

abnormal glial cell morphology ( J:197886 )

• E18.5 glial cells exhibit a fried egg morphology in culture unlike wild-type cells

abnormal neuronal precursor proliferation ( J:197886 )

• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice

• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice

abnormal cortical plate morphology ( J:197886 )

• decreased cell number at E16.5

abnormal cortical ventricular zone morphology ( J:197886 )

• decreased cell number at E16.5

• nuclei lose their apical-basal direction

decreased cortical ventricular zone cell density ( J:197886 )

• decreased cell number at E16.5

abnormal brain ependyma morphology ( J:197886 )

• clustering of the ependymal cells

• lack of lining ependymal cells inside the third ventricle, aqueduct and spinal cord central canal

enlarged brain ventricles ( J:197886 )

• bilateral

abnormal lateral ventricle morphology ( J:197886 )

• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain

• neuronal cells lining the lateral ventricle lack apical membrane domain

abnormal third ventricle morphology ( J:197886 )

• lack of lining ependymal cells

abnormal cerebral aqueduct morphology ( J:197886 )

• lack of lining ependymal cells

cerebral aqueductal stenosis ( J:197886 )

abnormal cerebral cortex morphology ( J:197886 )

• slight increase in cell numbers with disruption of cell polarization at E14.5

• flattened surface with hypoplasia

abnormal neocortex morphology ( J:197886 )

• abnormal orientation at E16.5 indicating a folding problem

thin cerebral cortex ( J:197886 )

• lacking ventricular and sub-ventricular zones

small olfactory bulb ( J:197886 )

• slightly

decreased neuronal precursor cell number ( J:197886 )

• decreased apical neuronal progenitor cell numbers in the cerebral cortex at E14.5 and E16.5

abnormal spinal cord central canal morphology ( J:197886 )

• collapse of the central canal and lack of differentiated ependymal cells

cellular

abnormal glial cell morphology ( J:197886 )

• E18.5 glial cells exhibit a fried egg morphology in culture unlike wild-type cells

abnormal cell nucleus morphology ( J:197886 )

• at E14.5 and E16.5, radial glial cell nuclei exhibit impaired interkinetic nuclear migration compared to in wild-type cells

abnormal neuronal precursor proliferation ( J:197886 )

• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice

• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice

behavior/neurological

absent gastric milk in neonates ( J:197886 )

decreased locomotor activity ( J:197886 )

• in neonates

cardiovascular system

intraventricular hemorrhage ( J:197886 )

• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain

respiratory system

respiratory distress ( J:197886 )

• in neonates