Phenotypes Associated with This Genotype

Genotype
MGI:5485172

• Allelic Composition: Smg1^{Gt(AG0297)Wtsi}/Smg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Lymphoma, chronic inflammation, papillary adenocarcinoma, and steatosis in Smg1^{Gt(AG0297)Wtsi}/Smg1⁺ mice

respiratory system

increased lung adenocarcinoma incidence ( J:193626 )

• papillary adenocarcinoma in the lung

mortality/aging

decreased tumor-free survival time ( J:193626 )

• due to high tumor incidence

neoplasm

increased tumor incidence ( J:193626 )

• in various organs

increased lymphoma incidence ( J:193626 )

• predominantly B cell of follicular center origin

increased B cell derived lymphoma incidence ( J:193626 )

• of follicular center origin

increased lung adenocarcinoma incidence ( J:193626 )

• papillary adenocarcinoma in the lung

craniofacial

abnormal basicranium angle ( J:193626 )

• the angle formed by the plane of the mandible to the plane of the cranial base is decreased compared to in wild-type mice

abnormal tooth morphology ( J:193626 )

• over-grown

abnormal tooth development ( J:193626 )

• producing over-grown teeth

prognathia ( J:193626 )

growth/size/body

abnormal tooth morphology ( J:193626 )

• over-grown

abnormal tooth development ( J:193626 )

• producing over-grown teeth

increased body size ( J:193626 )

increased body weight ( J:193626 )

increased body length ( J:193626 )

enlarged liver ( J:193626 )

enlarged spleen ( J:193626 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:193626 )

N • IGF-1 serum levels are normal

decreased circulating interleukin-1 beta level ( J:193626 )

increased circulating interleukin-6 level ( J:193626 )

immune system

enlarged spleen ( J:193626 )

decreased circulating interleukin-1 beta level ( J:193626 )

increased circulating interleukin-6 level ( J:193626 )

chronic inflammation ( J:193626 )

• low level inflammation that progresses to chronic inflammation

• mainly in the kidney and lung

liver/biliary system

enlarged liver ( J:193626 )

hepatic steatosis ( J:193626 )

renal/urinary system

abnormal kidney morphology ( J:193626 )

cellular

cellular phenotype ( J:193626 )

N • mice exhibit normal nonsense-mediated decay and stress responses

skeleton

skeleton phenotype ( J:193626 )

N • aside from craniofacial defects, skeleton morphology is normal

abnormal basicranium angle ( J:193626 )

• the angle formed by the plane of the mandible to the plane of the cranial base is decreased compared to in wild-type mice

abnormal tooth morphology ( J:193626 )

• over-grown

abnormal tooth development ( J:193626 )

• producing over-grown teeth

prognathia ( J:193626 )

hematopoietic system

hematopoietic system phenotype ( J:193626 )

N • mice exhibit normal hematopoietic compartment composition

enlarged spleen ( J:193626 )