Phenotypes Associated with This Genotype

Genotype
MGI:5431583

• Allelic Composition: Dicer1^tm1Smr/Dicer1^tm1Smr; Tg(KRT5-rtTA)1Glk/0; Tg(tetO-cre)1Jaw/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:183487 )

N • doxycycline-treated mice retain hair follicle stem cells in early telogen and anagen

abnormal coat/ hair morphology ( J:183487 )

• hair phenotype in doxycycline-treated mice appears more rapidly than in Drosha^tm1Litt/Drosha^tm1Litt Tg(KRT5-rtTA)1Glk Tg(tetO-cre)1Jaw mice

abnormal hair growth ( J:183487 )

• failure of hair regrowth in doxycycline-treated mice

• failure of regression at P20 in doxycycline-treated mice and remained in an abnormal growth phase

• following hair plucking, doxycycline-treated mice fail to sustain hair growth unlike control mice

alopecia ( J:183487 )

• after P14 in doxycycline-treated mice

waved hair ( J:183487 )

• external hair becomes wavy between P12 and P14 in doxycycline-treated mice

abnormal hair shaft morphology ( J:183487 )

• in doxycycline-treated mice likely due to matrix cell apoptosis

abnormal hair follicle morphology ( J:183487 )

• at P17 in doxycycline-treated mice after degradation begins

abnormal hair follicle inner root sheath morphology ( J:183487 )

• fewer differentiation cell in doxycycline-treated mice following plucking-induced anagen initiation

abnormal hair follicle bulge morphology ( J:183487 )

• at P59 doxycycline-treated mice exhibit loss of bulge stem cells unlike in control mice

• however, bulge stem cells are present at P20 and P22

hair follicle degeneration ( J:183487 )

• with extrusion of abnormally keratinized cellular material in doxycycline-treated mice

small hair follicles ( J:183487 )

• in doxycycline-treated mice following plucking-induced anagen initiation

abnormal hair cycle catagen phase ( J:183487 )

• failure of catagen in doxycycline-treated mice

abnormal hair follicle regression ( J:183487 )

• failure of regression at P20 in doxycycline-treated mice

epidermal hyperplasia ( J:183487 )

• by P20, doxycycline-treated mice exhibit thickened interfollicular epidermis compared with control mice

dry skin ( J:183487 )

• mice treated with doxycycline exhibit a temporary phenotype of dry scaly skin that is resolved in an anterior-posterior direction

scaly skin ( J:183487 )

• mice treated with doxycycline exhibit a temporary phenotype of dry scaly skin that is resolved in an anterior-posterior direction

abnormal skin physiology ( J:183487 )

cellular

increased apoptosis ( J:183487 )

• doxycycline-treated mice exhibit matrix cell apoptosis with DNA damage response unlike in control mice

growth/size/body

decreased body size ( J:183487 )

• in doxycycline-treated mice