About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5014310
Allelic
Composition
Tg(Upk2-TAg)1Rkl/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype

Urothelial carcinoma in situ in Tg(Upk2-TAg)1Rkl/0 mice

neoplasm
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal
• one mouse exhibited lamina propria invasion
• all mice develop bladder urothelial carcinoma in situ
• male mice develop higher bladder weight due to higher tumor burden compared with female mice
• a flat growth with large and pleomorphic nuclei and frequent mitoses

renal/urinary system
• all mice develop bladder urothelial carcinoma in situ
• male mice develop higher bladder weight due to higher tumor burden compared with female mice
• a flat growth with large and pleomorphic nuclei and frequent mitoses
• male mice develop higher bladder weight due to higher tumor burden compared with female mice

homeostasis/metabolism
• tumors exhibit hypoxia

cardiovascular system
• tumors develop prominent vasculature
• tumors exhibit hypoxia
• however, pericyte coverage is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
urinary bladder cancer DOID:11054 OMIM:109800
J:173505


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory