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Tg(Upk2-TAg)1Rkl
Transgene Detail
Summary
Symbol: Tg(Upk2-TAg)1Rkl
Name: transgene insertion 1, Raghu Kalluri
MGI ID: MGI:5014305
Synonyms: UPK II-SV40
Transgene: Tg(Upk2-TAg)1Rkl  Location: unknown  
Alliance: Tg(Upk2-TAg)1Rkl page
Urothelial carcinoma in situ in Tg(Upk2-TAg)1Rkl/0 mice

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThe mouse promoter drives urinary bladder-specific expression of the SV40 large T antigen with a polyadenylation sequence. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:173505)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:173505 Ayala de la Pena F, et al., Loss of p53 and Acquisition of Angiogenic MicroRNA Profile Are Insufficient to Facilitate Progression of Bladder Urothelial Carcinoma in Situ to Invasive Carcinoma. J Biol Chem. 2011 Jun 10;286(23):20778-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory