Phenotypes Associated with This Genotype

Genotype
MGI:4943704

• Allelic Composition: Fas^lpr/Fas^lpr; Il27ra^tm1Mak/Il27ra^tm1Mak
• Genetic Background: MRL.Cg-Il27ra^tm1Mak Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

extended life span ( J:122148 )

• 10% of mice die by week 24 compared with 50% of Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

immune system

immune system phenotype ( J:122148 )

N • mice exhibit unaltered lymphocyte compartment compared with Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased IgE level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased IgG1 level ( J:122148 )

• mice exhibit increased IgG1 depositions in the kidneys compared with Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

• IgG1 serum levels are increased compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

decreased IgG2a level ( J:122148 )

• mice exhibit reduced IgG2a renal deposits and serum levels compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

abnormal T-helper 2 physiology ( J:122148 )

• Th2-type immune response is favored compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased circulating interleukin-4 level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased circulating interleukin-5 level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

decreased interferon-gamma secretion ( J:122148 )

• 10-fold in stimulated CD4+ T cells compared with similarly treated Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ cells

decreased susceptibility to systemic lupus erythematosus ( J:122148 )

• mice exhibit improved survival, creatinine serum level, blood urea nitrogen serum level, and renal injury compared with Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

decreased anti-double stranded DNA antibody level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

glomerulonephritis ( J:122148 )

• mice develop membranous glomerulonephritis

renal/urinary system

glomerulonephritis ( J:122148 )

• mice develop membranous glomerulonephritis

homeostasis/metabolism

decreased circulating creatinine level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

decreased blood urea nitrogen level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased circulating interleukin-4 level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased circulating interleukin-5 level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

hematopoietic system

increased IgE level ( J:122148 )

• compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

increased IgG1 level ( J:122148 )

• mice exhibit increased IgG1 depositions in the kidneys compared with Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

• IgG1 serum levels are increased compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

decreased IgG2a level ( J:122148 )

• mice exhibit reduced IgG2a renal deposits and serum levels compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

abnormal T-helper 2 physiology ( J:122148 )

• Th2-type immune response is favored compared to in Fas^lpr/Fas^lpr Il27ra^tm1Mak/Il27ra⁺ mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
membranous glomerulonephritis		DOID:10976		J:122148