Il27ra^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Il27ra^tm1Mak
• Name: interleukin 27 receptor, alpha; targeted mutation 1, Tak Mak
• MGI ID: MGI:3040914
• Synonyms: IL-27R^-, Il27ra-, Wsx1^-, WSX-1-
• Gene: Il27ra Location: Chr8:84756923-84769218 bp, - strand Genetic Position: Chr8, 40.26 cM, cytoband C3
• Alliance: Il27ra^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:89509
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An exon encoding a portion of the extracellular fibronectin type III domain was replaced with a neo cassette. Western blot demonstrated lack of protein in mutant spleen cells. (J:89509)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il27ra Mutation: 29 strains or lines available

References

• Original: J:89509 Yoshida H, et al., WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity. 2001 Oct;15(4):569-78
• All: 102 reference(s)