Phenotypes Associated with This Genotype

Genotype
MGI:4456369

• Allelic Composition: Tg(KRT5-IKBKB)1Armz/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:160072 )

N • 50% of mice have alterations in exocrine glands

craniofacial

abnormal tooth morphology ( J:160072 )

• 50% of mice have alterations in teeth

pigmentation

hyperpigmentation ( J:160072 )

• in approximately 10% of mice

immune system

increased interleukin-1 alpha secretion ( J:160072 )

• in the supernatants after 48 hours of culture compared to wild-type keratinocytes

increased interleukin-6 secretion ( J:160072 )

• in the supernatants after 48 hours of culture compared to wild-type keratinocytes

increased tumor necrosis factor secretion ( J:160072 )

• in the supernatants after 48 hours of culture compared to wild-type keratinocytes

integument

alopecia ( J:160072 )

• in approximately 10% of mice

hairless ( J:160072 )

• in approximately 10% of mice

progressive hair loss ( J:160072 )

• in approximately 10% of mice

reddish skin ( J:160072 )

• in approximately 10% of mice

spontaneous skin ulceration ( J:160072 )

• in approximately 10% of mice

abnormal skin condition ( J:160072 )

• about 10% develop a skin condition that leads to lichenification (characterized by thickened, hyperpigmented, and hairless skin)

• alterations in the skin are detected in the first month of life

thick skin ( J:160072 )

• in approximately 10% of mice

abnormal keratinocyte physiology ( J:160072 )

• increase in the production and secretion of IL1A, IL6, TNF, CSF2 and CCL2 in keratinocytes cultured for 48 hours

decreased keratinocyte apoptosis ( J:160072 )

• more resistant to apoptosis than wild-type keratinocytes resulting in an almost 2-fold increase in the percentage of cell survival in response to TNF-alpha and cyclohexamide

increased pruritus ( J:160072 )

• in approximately 10% of mice

cellular

decreased keratinocyte apoptosis ( J:160072 )

• more resistant to apoptosis than wild-type keratinocytes resulting in an almost 2-fold increase in the percentage of cell survival in response to TNF-alpha and cyclohexamide

growth/size/body

abnormal tooth morphology ( J:160072 )

• 50% of mice have alterations in teeth

skeleton

abnormal tooth morphology ( J:160072 )

• 50% of mice have alterations in teeth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dermatitis		DOID:2723		J:160072