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Tg(KRT5-IKBKB)1Armz
Transgene Detail
Summary
Symbol: Tg(KRT5-IKBKB)1Armz
Name: transgene insertion 1, Angel Ramirez
MGI ID: MGI:4456367
Transgene: Tg(KRT5-IKBKB)1Armz  Location: unknown  
Alliance: Tg(KRT5-IKBKB)1Armz page
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(KRT5-IKBKB)1Armz expresses 1 gene
 
Tg(KRT5-IKBKB)1Armz expression driven by 1 gene
 
Mutation detailsThis transgene expresses N-terminal vesicular stomatitis virus (VSV) epitope-tagged human inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (IKBKB) under control of the 5.2 kb 5' upstream fragment of the bovine keratin 5 (KRT5) gene and a rabbit b-globin intron. Line 1 incorporated the transgene into an autosome. Immunohistochemical analysis using antibodies against IKBKB or the VSV epitope revealed expression of the protein in basal cells of the skin and of other stratified epithelia (e.g., palate and forestomach) and in hair follicles. (J:160072)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(KRT5-IKBKB)1Armz
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:160072 Page A, et al., IKKbeta leads to an inflammatory skin disease resembling interface dermatitis. J Invest Dermatol. 2010 Jun;130(6):1598-610
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/02/2024
MGI 6.23
The Jackson Laboratory