Phenotypes Associated with This Genotype

Genotype
MGI:4410367

cx4

• Allelic Composition: Chd7^Whi/Chd7⁺; Tbx1^tm1Bld/Tbx1⁺
• Genetic Background: B6.Cg-Chd7^Whi Tbx1^tm1Bld

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Malformations of the semicircular canals in Chd7^Whi/Chd7⁺, Tbx1^tm1Bld/Tbx1⁺, and Chd7^Whi/Chd7⁺ Tbx1^tm1Bld/Tbx1⁺ mice

hearing/vestibular/ear

abnormal lateral semicircular canal morphology ( J:154590 )

• all mice exhibit defects in the lateral canal including canal truncation (16%), presence of only the ampulla (67%), or absence of the canal (17%) unlike wild-type mice

absent lateral semicircular canal ( J:154590 )

• in 17% of mice

abnormal posterior semicircular canal morphology ( J:154590 )

• 58% mice exhibit posterior canal truncations unlike wild-type mice

• 42% of mice exhibit posterior canal fused to the crus commune unlike wild-type mice