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Phenotypes Associated with This Genotype
Genotype
MGI:4361938
Allelic
Composition
Il4ratm2Tch/Il4ratm2Tch
Genetic
Background
C.129X1-Il4ratm2Tch
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il4ratm2Tch mutation (1 available); any Il4ra mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Lung histology staining of OVA-sensitized control (Q576) and Il4ratm2Tch/Il4ratm2Tch (R576) mice challenged intranasally with OVA on three consecutive days

respiratory system
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control
• OVA sensitized and challenged mutant (R576) mice exhibit patchy peribronchial inflammatory infiltrate that is more prominent that in Q576 controls
• peribronchial infiltrate is composed primarily of eosinophils and lymphoctyes
• OVA or IL13 challenged mice exhibit goblet cell hyperplasia
• enhanced response to IL13 challenge

immune system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13
• stimulated Th2 cells exhibit an increase in IL4 production
• enhanced allergic inflammatory response following IL13 challenge
• mutant mice exhibit airway inflammation following chronic allergen challenge
• increase in peribronchial and perivascular inflammation compared with control

hematopoietic system
• increase in eosinophils found in lung parenchyma of OVA sensitized mutant mice
• increase in monocytes found in lung parenchyma of OVA sensitized mutant mice
• following immunization with OVA or alum
• stimulated Th2 cells exhibit an increase in IL4 production, but not IL5 or IL13

homeostasis/metabolism
• stimulated Th2 cells exhibit an increase in IL4 production

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
asthma DOID:2841 OMIM:600807
J:152376


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory