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Phenotypes Associated with This Genotype
Genotype
MGI:4358724
Allelic
Composition
Dtnbp1sdy/Dtnbp1sdy
Genetic
Background
DBA/2J-Dtnbp1sdy/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dtnbp1sdy mutation (1 available); any Dtnbp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation

behavior/neurological
• mice exhibit a smaller increase in locomotor activity following acute amphetamine treatment compared to wild-type mice
• following an amphetamine challenge, a significant increase in the locomotor activity is seen in amphetamine pre-treated mutants compared to amphetamine pre-treated wild-type mice
• mutants exhibit increased freezing to an auditory tone compared to wild-type controls, suggesting enhanced amygdala-related fear memory
• however, contextual memory appears to be intact
• mutants do not show a decrease in locomotor activity from day 1 to day 7 in a novel environment, indicating lack of habituation to the environment that is seen in wild-type mice
• after 5 min of retention interval, mutants spend less time exploring a new object compared to controls indicating impaired short-term object recognition memory
• mutants take more time in removing their paw from a high intensity beam indicating less sensitivity to thermal nociception

vision/eye

homeostasis/metabolism

integument

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
schizophrenia DOID:5419 OMIM:181500
J:143912


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory