Phenotypes Associated with This Genotype

Genotype
MGI:3843612

• Allelic Composition: Lig1^tm1Dwm/Lig1^tm1Dwm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:76371 )

• although mice are present at E15.5, no mice are alive at E16.5

hematopoietic system

abnormal blood cell morphology/development ( J:76371 )

• at E15.5, the total number of circulating blood cells is 5% of that in wild-type mice

• the number of primitive multipotent (CFU-A) and erythroid (BFU-E) progenitors in the liver are decreased compared to in wild-type mice

• liver suspensions are unable to rescue lethally irradiated mice

abnormal erythropoiesis ( J:76371 )

• liver erythropoiesis is disrupted

• however, yolk sac erythropoiesis is normal

anemia ( J:76371 )

• at E15.5

decreased erythroid progenitor cell number ( J:76371 )

• the number of erythroid (BFU-E) progenitors in the liver are decreased compared to in wild-type mice

absent erythrocytes ( J:76371 )

• at E15.5, mice lack mature enucleated erythrocytes

anisocytosis ( J:76371 )

poikilocytosis ( J:76371 )

embryo

embryonic growth retardation ( J:76371 )

• at E10.5

decreased embryo size ( J:76371 )

• at E11.5

liver/biliary system

abnormal liver development ( J:76371 )

• at E15.5, livers lack erythropoietic islands and lack extensive cellularization compared with wild-type livers

• however, hepatocytes and megakaryocytes appear normal

small liver ( J:76371 )

liver hypoplasia ( J:76371 )

• fewer erythroid hematopoietic cells are found within the liver compared to in wild-type mice

• however, the number of non-erythoid hematopoeitic cells is normal

growth/size/body

embryonic growth retardation ( J:76371 )

• at E10.5

decreased embryo size ( J:76371 )

• at E11.5

integument

pallor ( J:76371 )

• embryos are pale at E11.5