Phenotypes Associated with This Genotype

Genotype
MGI:3839581

• Allelic Composition: Bcl11b^tm1.2Leid/Bcl11b^tm1.2Leid
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defects in tooth development in Bcl11b^tm1.2Leid/Bcl11b^tm1.2Leid mice

craniofacial

abnormal incisor morphology ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side

• at E16.5 an expansion of the epithelium is seen on the lingual side and the stellate reticulum on the labial side is indiscernible

• at E16.5 the outer enamel epithelium is hypoplastic and the odontoblasts appear disorganized

small incisors ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

small molars ( J:146765 )

• molars are slightly smaller than in controls at all stages examined

• at E14.5 molar buds are smaller with a slightly elongated dental cord

• at E16.5 and E18.5 molars are smaller and underdeveloped with a poorly defined enamel knot and hypoplastic stellate reticulum

abnormal tooth development ( J:146765 )

• at E14.5 incisor and molar buds are smaller with an elongated dental cord and this defect persists at E16.5

abnormal odontoblast morphology ( J:146765 )

• at E16.5 odontoblasts appear disorganized but this effect is less severe than the disruption of cells of the ameloblast lineage

abnormal ameloblast morphology ( J:146765 )

• at E16.5 the ameloblasts appear disorganized and are not polarized unlike in controls

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side, indicating loss of lingual/labial asymmetry of ameloblasts

abnormal ameloblast differentiation ( J:146765 )

• at E18.5 expression analysis indicates that ameloblast differentiation and structural integrity are impaired

abnormal stellate reticulum morphology ( J:146765 )

• at E16.5, the stellate reticulum on the labial side of incisors is indiscernible/reduced

• at E16.5 and E18.5, molars display a hypoplastic stellate reticulum

abnormal enamel knot morphology ( J:146765 )

• at E16.5 and E18.5, molars show a poorly defined enamel knot

abnormal outer dental epithelium morphology ( J:146765 )

• the outer enamel epithelium is hypoplastic

abnormal enamel cord morphology ( J:146765 )

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E14.5 molar buds are smaller with a slightly elongated dental cord

skeleton

abnormal incisor morphology ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side

• at E16.5 an expansion of the epithelium is seen on the lingual side and the stellate reticulum on the labial side is indiscernible

• at E16.5 the outer enamel epithelium is hypoplastic and the odontoblasts appear disorganized

small incisors ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

small molars ( J:146765 )

• molars are slightly smaller than in controls at all stages examined

• at E14.5 molar buds are smaller with a slightly elongated dental cord

• at E16.5 and E18.5 molars are smaller and underdeveloped with a poorly defined enamel knot and hypoplastic stellate reticulum

abnormal tooth development ( J:146765 )

• at E14.5 incisor and molar buds are smaller with an elongated dental cord and this defect persists at E16.5

abnormal odontoblast morphology ( J:146765 )

• at E16.5 odontoblasts appear disorganized but this effect is less severe than the disruption of cells of the ameloblast lineage

abnormal ameloblast morphology ( J:146765 )

• at E16.5 the ameloblasts appear disorganized and are not polarized unlike in controls

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side, indicating loss of lingual/labial asymmetry of ameloblasts

abnormal ameloblast differentiation ( J:146765 )

• at E18.5 expression analysis indicates that ameloblast differentiation and structural integrity are impaired

abnormal stellate reticulum morphology ( J:146765 )

• at E16.5, the stellate reticulum on the labial side of incisors is indiscernible/reduced

• at E16.5 and E18.5, molars display a hypoplastic stellate reticulum

abnormal enamel knot morphology ( J:146765 )

• at E16.5 and E18.5, molars show a poorly defined enamel knot

abnormal outer dental epithelium morphology ( J:146765 )

• the outer enamel epithelium is hypoplastic

abnormal enamel cord morphology ( J:146765 )

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E14.5 molar buds are smaller with a slightly elongated dental cord

growth/size/body

abnormal incisor morphology ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side

• at E16.5 an expansion of the epithelium is seen on the lingual side and the stellate reticulum on the labial side is indiscernible

• at E16.5 the outer enamel epithelium is hypoplastic and the odontoblasts appear disorganized

small incisors ( J:146765 )

• incisors are slightly smaller than in controls at all stages examined

small molars ( J:146765 )

• molars are slightly smaller than in controls at all stages examined

• at E14.5 molar buds are smaller with a slightly elongated dental cord

• at E16.5 and E18.5 molars are smaller and underdeveloped with a poorly defined enamel knot and hypoplastic stellate reticulum

abnormal tooth development ( J:146765 )

• at E14.5 incisor and molar buds are smaller with an elongated dental cord and this defect persists at E16.5

abnormal odontoblast morphology ( J:146765 )

• at E16.5 odontoblasts appear disorganized but this effect is less severe than the disruption of cells of the ameloblast lineage

abnormal ameloblast morphology ( J:146765 )

• at E16.5 the ameloblasts appear disorganized and are not polarized unlike in controls

• at E16.5 cells resembling ameloblasts are found on both the labial and lingual sides of incisors unlike in controls where these cells are confined to the labial side, indicating loss of lingual/labial asymmetry of ameloblasts

abnormal ameloblast differentiation ( J:146765 )

• at E18.5 expression analysis indicates that ameloblast differentiation and structural integrity are impaired

abnormal stellate reticulum morphology ( J:146765 )

• at E16.5, the stellate reticulum on the labial side of incisors is indiscernible/reduced

• at E16.5 and E18.5, molars display a hypoplastic stellate reticulum

abnormal enamel knot morphology ( J:146765 )

• at E16.5 and E18.5, molars show a poorly defined enamel knot

abnormal outer dental epithelium morphology ( J:146765 )

• the outer enamel epithelium is hypoplastic

abnormal enamel cord morphology ( J:146765 )

• at E14.5 incisor buds are smaller with an elongated dental cord and this defect persists at E16.5

• at E14.5 molar buds are smaller with a slightly elongated dental cord