Phenotypes Associated with This Genotype

Genotype
MGI:3838615

• Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺; Pdgfra^tm12Sor/Pdgfra⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:146617 )

• 6 months after tamoxifen treatment, mice develop intestinal disease and eventually die or are sacrificed

digestive/alimentary system

abnormal cecum morphology ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

abnormal small intestine morphology ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

intestinal fibrosis ( J:146617 )

• tamoxifen-treated mice exhibit partial or complete fibrosis of the small intestine and cecum unlike in wild-type mice with increased submucosal connective tissue and proportional increase in fibroblast-like cells and collagenous matrix

intestine polyps ( J:146617 )

• in tamoxifen-treated mice

cardiovascular system

cardiac fibrosis ( J:146617 )

• in tamoxifen-treated mice

renal/urinary system

glomerulosclerosis ( J:146617 )

• sclerotic glomeruli in tamoxifen-treated mice

renal glomerulus fibrosis ( J:146617 )

• in tamoxifen-treated mice

renal glomerulus hypertrophy ( J:146617 )

• enlarged glomeruli in tamoxifen-treated mice

renal interstitial fibrosis ( J:146617 )

• in tamoxifen-treated mice

neoplasm

increased sarcoma incidence ( J:146617 )

• at between 44 and 76 weeks of age, 5 of 29 tamoxifen-treated mice develop sarcomas arising from dermis or muscle connective tissue

muscle

skeletal muscle interstitial fibrosis ( J:146617 )

• in tamoxifen-treated mice

respiratory system

pulmonary fibrosis ( J:146617 )

• around the bronchioles in tamoxifen-treated mice

integument

tight skin ( J:146617 )

• in tamoxifen-treated mice