Phenotypes Associated with This Genotype

Genotype
MGI:3819787

• Allelic Composition: Chrd^tm1Emdr/Chrd^tm1Emdr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:123318 )

• about 50% of animals die perinatally

nervous system

nervous system phenotype ( J:123318 )

N • at 2-3 months of age brains show normal gross hippocampal morphology as well as normal dendritic structure

abnormal brain development ( J:123318 )

• axon terminals at hippocampal synapses have more docked vesicles per active zone length than wild-type synapses

enhanced long-term potentiation ( J:123318 )

• LTP induction is enhanced with high frequency stimulation of afferent fibers compared to wild-type controls

abnormal miniature excitatory postsynaptic currents ( J:123318 )

• frequency of mEPSCs in hippocampal slices is significantly increased compared to controls while amplitudes are similar

increased neurotransmitter release ( J:123318 )

enhanced paired-pulse facilitation ( J:123318 )

• in mutant CA1 region hippocampal slices significantly enhanced paired-pulse facilitation (PPF) is observed compared to wild-type slices at interpulse intervals <100 ms

behavior/neurological

decreased exploration in new environment ( J:123318 )

• in Y-maze test mice enter formerly closed (novel) arm of maze less frequently than wild-type controls during recall trial (3 hours after acquisition phase)

abnormal spatial learning ( J:123318 )

• in Morris water maze mice display improved ability to find hidden platform using spatial cues and require less time to escape from water on second day of experiment; after 10 days of training wild-type and mutants show similar performance

abnormal response to novel object ( J:123318 )

• mice display lower sniffing behavior to a novel object placed inside their box during a 15 minute test

hyperactivity ( J:123318 )

• in center of open field mice exhibit hyperactivity and run faster than wild-type controls