Analysis Tools
mortality/aging
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• though 75% of mice die during embryogenesis, mice born live at least until 12 months of age
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• 75% of mice die during embryogenesis
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immune system
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• splenic B cells have a slightly enhanced migratory response to the chemokine CXCL12
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• B cells activated in vitro with LPS have significantly higher proliferation rates
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• mature CD4+ T cells accumulate in the medulla of the thymus
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• immature B cells numbers are reduced by almost half in the bone marrow of adult mice
• newly formed B cells are reduced by 20-30% in the spleen of adult mice
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• T1 and T2 transitional B cells are reduced by 20-30% in the spleen of adult mice
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• the proportion of eosinophils in the bone marrow is three times higher than in controls
• increased numbers of eosinophils are also observed in the lung
• these increase numbers correlate with an increased amount of circulating IL-5
• these eosinophil differences are more clearly observed between the 12- to 55-wk-old groups than between the 6- and 11-wk-old groups
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• mature B cell numbers are reduced by more than half in the bone marrow of adult mice
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• follicular B cells are reduced by 20-30% in the spleen of adult mice
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• MZ B cells are virtually absent in the spleen of adult mice
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• pre-B cell numbers are reduced in the bone marrow to varying degrees depending on age
• numbers are reduced by about 25% at 7 weeks of age and by over 50% at 12-32 weeks of age
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• there is a 80-90% reduction in the number of circulating T cells found in adults
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• the percentage of double-positive thymocytes is reduced by 30% compared to controls at 18 weeks of age
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• the percentages of single-positive thymocytes are increased 2-fold
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• spleen cellularity is reduced in these mice
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• localization of B cells is disorganized in the border region of the white pulp
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• splenic T cells have reduced migratory responses to CXCL12, CCL21, and CCL19
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• T cells activated in vitro have significantly less proliferation than controls
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• the average serum concentrations of IL-5 (17 pg/ml vs 4.5 pg/ml in WT) are significantly increased
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• while reduced B cells are found throughout the rest of the body, mesenteric lymph nodes have 2- to 3- fold increased numbers of B cells
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• there are increases in the size and cellular densities of B cell follicles within the mesenteric lymph nodes
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endocrine/exocrine glands
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• mature CD4+ T cells accumulate in the medulla of the thymus
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• testes showed drastic testicular degeneration
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hematopoietic system
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• splenic B cells have a slightly enhanced migratory response to the chemokine CXCL12
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• B cells activated in vitro with LPS have significantly higher proliferation rates
|
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• mature CD4+ T cells accumulate in the medulla of the thymus
|
|
• immature B cells numbers are reduced by almost half in the bone marrow of adult mice
• newly formed B cells are reduced by 20-30% in the spleen of adult mice
|
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• T1 and T2 transitional B cells are reduced by 20-30% in the spleen of adult mice
|
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• the proportion of eosinophils in the bone marrow is three times higher than in controls
• increased numbers of eosinophils are also observed in the lung
• these increase numbers correlate with an increased amount of circulating IL-5
• these eosinophil differences are more clearly observed between the 12- to 55-wk-old groups than between the 6- and 11-wk-old groups
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• mature B cell numbers are reduced by more than half in the bone marrow of adult mice
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• follicular B cells are reduced by 20-30% in the spleen of adult mice
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• MZ B cells are virtually absent in the spleen of adult mice
|
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• pre-B cell numbers are reduced in the bone marrow to varying degrees depending on age
• numbers are reduced by about 25% at 7 weeks of age and by over 50% at 12-32 weeks of age
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• there is a 80-90% reduction in the number of circulating T cells found in adults
|
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• the percentage of double-positive thymocytes is reduced by 30% compared to controls at 18 weeks of age
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• the percentages of single-positive thymocytes are increased 2-fold
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• spleen cellularity is reduced in these mice
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• localization of B cells is disorganized in the border region of the white pulp
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• splenic T cells have reduced migratory responses to CXCL12, CCL21, and CCL19
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• T cells activated in vitro have significantly less proliferation than controls
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homeostasis/metabolism
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• the average serum concentrations of IL-5 (17 pg/ml vs 4.5 pg/ml in WT) are significantly increased
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reproductive system
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• testes showed drastic testicular degeneration
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• male mice are totally sterile
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cellular
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• splenic B cells have a slightly enhanced migratory response to the chemokine CXCL12
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• B cells activated in vitro with LPS have significantly higher proliferation rates
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• T cells activated in vitro have significantly less proliferation than controls
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