Arhgdib^tm1Miyo
Targeted Allele Detail

Summary

• Symbol: Arhgdib^tm1Miyo
• Name: Rho, GDP dissociation inhibitor beta; targeted mutation 1, Jun Miyoshi
• MGI ID: MGI:3814585
• Synonyms: Rho GDIbeta, RhoGDIbeta
• Gene: Arhgdib Location: Chr6:136900653-136918895 bp, - strand Genetic Position: Chr6, 66.72 cM, cytoband G1
• Alliance: Arhgdib^tm1Miyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140671
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1.7-kb DNA region covering the promoter region and exons 1 and 2 of the gene locus was replaced by a neomycin resistance cassette. Gene inactivation was confirmed by immunoblot assay on T and B lymphocyte cells collected from the spleen (J:140671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgdib Mutation: 16 strains or lines available

References

• Original: J:140671 Ishizaki H, et al., Defective chemokine-directed lymphocyte migration and development in the absence of Rho guanosine diphosphate-dissociation inhibitors alpha and beta. J Immunol. 2006 Dec 15;177(12):8512-21
• All: 1 reference(s)