Phenotypes Associated with This Genotype

Genotype
MGI:3772702

• Allelic Composition: Pde6b^rd1/Pde6b^rd1
• Genetic Background: C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retinal degeneration in Pde6b^rd1/Pde6b^rd1, and Pde6b^rd1/Pde6b^rd1 Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn mouse retinas

vision/eye

vision/eye phenotype ( J:123259 )

N • despite the absence of rods, mice exhibit normal photopotentiation (defined as a 50% augmentation in pupillary light response (PLR) compared to pre-bright light PLR during a one minute dim blue light exposure after bright light exposure)

absent photoreceptor outer segment ( J:66580 )

abnormal retina outer nuclear layer morphology ( J:66580 )

• nearly complete absence of outer nuclear layer

retina degeneration ( J:66580 )

• entire outer retina is destroyed, however the inner retina remains intact

nervous system

absent photoreceptor outer segment ( J:66580 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
retinitis pigmentosa 40		DOID:0110375	OMIM:613801	J:140115