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Phenotype Image Detail
Image
Caption Retina of 120 day old Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn (B) mouse is histologically indistinguishable from a wild type retina (A). Similarly, the retina of the Pde6brd1/Pde6brd1 Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn (D) is indistinguishable from that of an age matched Pde6brd1/Pde6brd1 (C) mouse in which essentially the entire outer retina is destroyed and the inner retina remains intact. Abbreviations: GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer; OS, outer segment; Chor, choroid. Note the nearly complete histologic absence of the ONL and OS in C and D.
Copyright This image is from Selby CP, Proc Natl Acad Sci U S A 2000 Dec 19;97(26):14697-702. Copyright 2000 National Academy of Sciences, U.S.A. J:66580
Associated
Alleles
Symbol Name
Cry1tm1Asn cryptochrome 1 (photolyase-like); targeted mutation 1, Aziz Sancar
Cry2tm1Asn cryptochrome 2 (photolyase-like); targeted mutation 1, Aziz Sancar
Pde6brd1 phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; retinal degeneration 1
Associated
Genotypes
Allelic Composition Genetic Background
Cry1tm1Asn/Cry1tm1Asn
Cry2tm1Asn/Cry2tm1Asn
Pde6brd1/Pde6brd1
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6
Pde6brd1/Pde6brd1 C3H/HeJ

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory