Cry1^tm1Asn
Targeted Allele Detail

Summary

• Symbol: Cry1^tm1Asn
• Name: cryptochrome circadian regulator 1; targeted mutation 1, Aziz Sancar
• MGI ID: MGI:2181211
• Synonyms: Cry-, Cry1^-, mCry1-
• Gene: Cry1 Location: Chr10:84967564-85020918 bp, - strand Genetic Position: Chr10, 41.63 cM, cytoband C
• Alliance: Cry1^tm1Asn page

Retinal degeneration in Pde6b^rd1/Pde6b^rd1, and Pde6b^rd1/Pde6b^rd1 Cry1^tm1Asn/Cry1^tm1Asn Cry2^tm1Asn/Cry2^tm1Asn mouse retinas

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58114
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region spanning nucleotides 686 and 1646, encoding the FAD-binding domain, was replaced by a cassette containing an Engrail-2 splice-acceptor site, an IRES, and a lacZ-neo fusion gene. (J:58114)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Cry1^tm1Asn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cry1 Mutation: 35 strains or lines available

References

• Original: J:58114 Vitaterna MH, et al., Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):12114-9
• All: 71 reference(s)