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Allele Symbol Allele Name Allele ID |
Cry1tm1Asn targeted mutation 1, Aziz Sancar MGI:2181211 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• circadian period for locomotor activity 1 hour shorter than wild-type controls in constant darkness
• capable of entrainment to light, however
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in the long bones and vertebrae
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| N |
• pupilary reflex is the same as in wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• substantial loss of constriction in response to light
• response is similar to that in mice homozygous for Pde6brd1 alone
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• substantial loss of constriction in response to light
• response is similar to that in mice homozygous for Pde6brd1 alone
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• activity period of 24.3 hours suggesting the period is partially dependent on an interaction between these two genes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Retinal degeneration in Pde6brd1/Pde6brd1, and Pde6brd1/Pde6brd1 Cry1tm1Asn/Cry1tm1Asn Cry2tm1Asn/Cry2tm1Asn mouse retinas
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• almost no pupillary reflex in blue light (470-nm)
• some pupillary movement in very bright light, but sluggish
• sensitivity to blue light is about 5% that of mice homozygous for Pde6brd1 only
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• arrhythmic circadian rhythms for locomotor activity in constant darkness
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• arrhythmic circadian rhythms for locomotor activity in light/dark cycles
• mutants accumulate nearly 40% of their total daily activity during the first 10 hours of the light portion of light-dark 12:12 compared with only 10% of activity during this same period seen with controls, indicating a residual photoresponsiveness in mutants
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• almost no pupillary reflex in blue light (470-nm)
• some pupillary movement in very bright light, but sluggish
• sensitivity to blue light is about 5% that of mice homozygous for Pde6brd1 only
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• most cones are absent
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• nearly complete absence of the outer nuclear layer
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• the entire outer retina is destroyed, however the inner retina remains intact
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• most cones are absent
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• immediate loss of rhythmicity when switched to constant darkness
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• dramatic decrease in subcutaneous fat mass
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• dramatic decrease in visceral fat mass
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• total body electrical conductivity is significantly decreased indicating a decrease in total body fat mass
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• lipid droplet size is decreased
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• seen from 5 weeks of age on
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• body temperature remains elevated during the light phase of the day-night cycle
• absence of diurnal rhythms in body temperature under 12 h dark light conditions
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• increased oxygen consumption during the light phase
• however, no significant difference is seen in respiratory quotient or carbohydrate consumption compared to wild-type controls
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• the peak level of glucose is delayed, maximal blood glucose level is increased, and plasma insulin levels at 15 and 30 min. after glucose challenge are decreased
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• plasma glucose levels are significantly lower during an insulin tolerance test
• however, pancreatic insulin secretory response to glucose are similar to wild-type controls
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• heart rate remains elevated during the light phase of the day-night cycle
• absence of diurnal rhythms in heart rate under 12 h dark light conditions
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• dramatic decrease in subcutaneous fat mass
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• absence of diurnal changes in activity when kept in constant darkness
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• enhanced spontaneous and induced baroreflex sensitivity and loss of diurnal oscillations in spontaneous and induced baroflex sensitivity under constant dark conditions
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• absence of diurnal changes in mean arterial pressure and baroflex sensitivity when kept in constant darkness
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• absence of an increase in mean arterial pressure in response to injection of 10ug/kg phenylephrine and only a small increase in response to injections of higher concentration
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• absence of an increase in mean arterial pressure in response to injection of 10ug/kg phenylephrine and only a small increase in response to injections of higher concentration
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant phase delay (2-4 hours) of circadian gene expression
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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