Phenotypes for Hydin MGI:3605005 MGI Mouse

mortality/aging

premature death ( J:13035 )

• usually die before 2 months of age, generally around 4-6 week

craniofacial

abnormal cranium morphology ( J:5426 )

• thin skull

wide cranial sutures ( J:5426 )

• open sutures

enlarged cranium ( J:13035 )

• skull volume doubled at birth, 0.88cc vs 0.44cc

• does not develop before 3-5 days after birth or possible the 2nd week of life

enlarged parietal bone ( J:13103 )

domed cranium ( J:13035 )

• develops after the first week of life

nervous system

hydrocephaly ( J:13035 )

abnormal brain interventricular foramen morphology ( J:13103 )

• foramina of Monro wider than normal

abnormal cerebral aqueduct morphology ( J:5377 )

• aqueduct of Sylvius occluded around 16 days of age

abnormal telencephalon morphology ( J:5377 )

• enlargement of extracellular spaces in the white matter after occlusion of the aqueduct of Sylvius

dilated lateral ventricle ( J:13035 )

• enormously dilated at birth

• thinning of pallium but basal ganglia less affected

• not apparent before 3-5 days of age

thin cerebral cortex ( J:5426 )

• cerebral cortex smooth and very thin

abnormal ependyma morphology ( J:5426 )

• flattened cells in the ependymal lining

abnormal brain meninges morphology ( J:13103 )

• calvarium tends to adhere more tightly to brain

• reduction of meningeal layers at 8 days of age

• swelling of cells in meninges in the area of the foramina of Luschka and the otic capsules

growth/size/body

cachexia ( J:13035 )

• eventually loose weight

• in an emaciated condition at the time of death

postnatal growth retardation ( J:13035 )

• general growth retardation

• never reach normal size

behavior/neurological

abnormal aggression-related behavior ( J:5426 )

• episodes of aggressive behavior

abnormal fear/anxiety-related behavior ( J:5426 )

• "cowering" behavior observed at 21 days of age

ataxia ( J:5426 )

decreased locomotor activity ( J:13035 )

• become inactive as they age

reproductive system

male infertility ( J:13035 )

• probably (N=1)

muscle

muscle spasm ( J:13103 )

• develop spasticity of the hind limbs

respiratory system

abnormal respiratory system physiology ( J:13035 , J:13103 )

• nasal discharge composed of squamous epithelia and polymorphonuclear leukocytes (J:13035)

• nasal discharge not seen in later studies (J:13103)

skeleton