Phenotypes Associated with This Genotype

Genotype
MGI:3580069

• Allelic Composition: Nf1^tm1Fcr/Nf1⁺; Trp53^tm1Tyj/Trp53⁺
• Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:58877 )

• cis-double heterozygotes died at 15 weeks and trans-double heterozygotes died at 25 weeks

neoplasm

increased fibrohistocytoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased lymphoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased neuroblastoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased carcinoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased malignant triton tumor incidence ( J:58877 )

• developed in cis-double heterozygotes

increased sarcoma incidence ( J:58877 )

• both cis- and trans-double heterozygotes developed sarcomas

increased leiomyosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased rhabdomyosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased neurofibrosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

integument

increased fibrohistocytoma incidence ( J:58877 )

• developed in cis-double heterozygotes

muscle

increased leiomyosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased rhabdomyosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

nervous system

increased neuroblastoma incidence ( J:58877 )

• developed in cis-double heterozygotes

increased neurofibrosarcoma incidence ( J:58877 )

• developed in cis-double heterozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neurofibromatosis 1		DOID:0111253	OMIM:162200	J:58877