Phenotypes Associated with This Genotype

Genotype
MGI:3511894

• Allelic Composition: Maoa^K284stopMaob^tm1Shih/Y
• Genetic Background: either: (involves: 129S/SvEv * 129S6/SvEvTac) or (involves: 129S4/SvJae * 129S6/SvEvTac)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:93356 )

♂ • exploratory activity is reduced as is time spent in the center of the field

increased aggression towards mice ( J:93356 )

♂ • in the resident-intruder test mutants display a significant increase in anti-social behavior with a decrease in latency to attack and increased time spent chasing the intruder, as well as a decrease in investigative behavior

increased anxiety-related response ( J:93356 )

♂ • in an elevated Plus-maze, mutants exhibit more freezing or crouching postures, fewer entries into either the open or closed arms, proportionally more entries into the closed arms, and fewer rearing events

homeostasis/metabolism

increased dopamine level ( J:93356 )

♂ • dopamine levels are increased 1.7-fold

increased noradrenaline level ( J:93356 )

♂ • brain levels of norepinephrine and phenylethylamine are increased 2.2-, and 15.7-fold, respectively

increased serotonin level ( J:93356 )

♂ • brain levels of serotonin are increased 8.5-fold