Maob^tm1Shih
Targeted Allele Detail

Summary

• Symbol: Maob^tm1Shih
• Name: monoamine oxidase B; targeted mutation 1, Jean C Shih
• MGI ID: MGI:2180752
• Synonyms: MAOB KO
• Gene: Maob Location: ChrX:16575521-16683605 bp, - strand Genetic Position: ChrX, 11.88 cM
• Alliance: Maob^tm1Shih page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43648
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neo cassette into exon 6 via homologous recombination resulting in a premature stop codon and protein truncation. Enzyme assays of brain and liver extracts from mutant mice demonstrated background levels of enzyme activity. Western blot and immunohistochemical analyses failed to detect protein product. (J:43648)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Maob Mutation: 11 strains or lines available

Notes

ES cell line = CCE (129S/SvEv-Gpi1^c) or J1 (129S4/SvJae).

References

• Original: J:43648 Grimsby J, et al., Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997 Oct;17(2):206-10
• All: 19 reference(s)