Phenotypes Associated with This Genotype

Genotype
MGI:3046100

• Allelic Composition: Chat^tm1Jrs/Chat^tm1Jrs; Tg(CAG-cre/Esr1*)1Lbe/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89596 )

• mutant mice die by P14 - P15 following treatment with 100 ug of tamoxifen on P0 which results in excision of the floxed sequence in greater than 50% of motor neurons

nervous system

abnormal innervation pattern to muscle ( J:89596 )

• following a low dose of tamoxifen (5 ug) on P0, which results in excision of the floxed sequence in 10-20% of motor neurons, an increase in doubly innervated neuromuscular junctions is seen

• in these doubly innervated neuromuscular junctions when a non-excised axon is present it is significantly larger than the excised axon

behavior/neurological

weakness ( J:89596 )

• mutant mice become noticeably weak by P9 following treatment with 100 ug of tamoxifen on P0